Evidence map›Paper›PMID 33057029›Full record

ArticleScientific reports2020

In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles.

Azadeh Mohtashamdolatshahi, Harald Kratz, Olaf Kosch, Ralf Hauptmann, Nicola Stolzenburg, Frank Wiekhorst, Ingolf Sack, Bernd Hamm, Matthias Taupitz, Jörg Schnorr

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Azadeh MohtashamdolatshahiExperimental Radiology, Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Chariteplatz 1, 10117, Berlin, Germany. Azadeh.Mohtashamdolatshahi@charite.de.
Harald KratzExperimental Radiology, Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Chariteplatz 1, 10117, Berlin, Germany.
Olaf KoschDepartment of Medical Physics and Metrological Information Technology, Physikalisch-Technische Bundesanstalt (PTB), Abbestrasse 2-12, 10587, Berlin, Germany.
Ralf HauptmannExperimental Radiology, Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Chariteplatz 1, 10117, Berlin, Germany.
Nicola StolzenburgExperimental Radiology, Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Chariteplatz 1, 10117, Berlin, Germany.
Frank WiekhorstDepartment of Medical Physics and Metrological Information Technology, Physikalisch-Technische Bundesanstalt (PTB), Abbestrasse 2-12, 10587, Berlin, Germany.
Ingolf SackExperimental Radiology, Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Chariteplatz 1, 10117, Berlin, Germany.
Bernd HammExperimental Radiology, Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Chariteplatz 1, 10117, Berlin, Germany.
Matthias TaupitzExperimental Radiology, Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Chariteplatz 1, 10117, Berlin, Germany.
Jörg SchnorrExperimental Radiology, Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Chariteplatz 1, 10117, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic Particle Imaging (MPI) is a new imaging modality, which maps the distribution of magnetic nanoparticles (MNP) in 3D with high temporal resolution. It thus may be suited for cardiovascular imaging. Its sensitivity and spatial resolution critically depend on the magnetic properties of MNP. Therefore, we used novel multicore nanoparticles (MCP 3) for in-vivo MPI in rats and analyzed dose requirements, sensitivity and detail resolution. 8 rats were examined using a preclinical MPI scanner (Bruker Biospin GmbH, Germany) equipped with a separate receive coil. MCP 3 and Resovist were administered intravenously (i.v.) into the rats' tail veins at doses of 0.1, 0.05 and 0.025 mmol Fe/kg followed by serial MPI acquisition with a temporal resolution of 46 volumes per second. Based on a qualitative visual scoring system MCP 3-MPI images showed a significantly (P ≤ 0.05) higher image quality than Resovist-MPI images. Morphological features such as vessel lumen diameters (D

Indexed as

AngiographyAnimalsAortaMagnetic Iron Oxide NanoparticlesMaleRatsRats, Sprague-DawleyVena Cava, Inferior

Identifiers

PMID33057029
PMCPMC7560824

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.