ArticleNature communications2020
Exploring and applying the substrate promiscuity of a C-glycosyltransferase in the chemo-enzymatic synthesis of bioactive C-glycosides.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
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- The Chemistry of Gliflozins: Recent Advancements in SGLT-2 Inhibitors.Cardiovascular & hematological agents in medicinal chemistry · 2026Review
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- Mechanistic elucidation of enzymaticRSC advances · 2025Article
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- Creating glycoside diversity through stereoselective carboboration of glycals.Nature communications · 2024Article
- UGT708S6 from Dendrobium catenatum, catalyzes the formation of flavonoid C-glycosides.BMC biotechnology · 2024Article
- An efficient C-glycoside production platform enabled by rationally tuning the chemoselectivity of glycosyltransferases.Nature communications · 2024Article
- Review
- Enzymatic glycosylation of aloesone performed by plant UDP-dependent glycosyltransferases.Glycobiology · 2024Article
- Unravelling and reconstructing the biosynthetic pathway of bergenin.Nature communications · 2024Article
- Harnessing Plant Sugar Metabolism for Glycoengineering.Biology · 2023Article
- A highly selectiveActa pharmaceutica Sinica. B · 2023Article
- Diversification of phenolic glucosides by two UDP-glucosyltransferases featuring complementary regioselectivity.Microbial cell factories · 2022Article
- Rapid Mining of NovelMarine drugs · 2022Article
- Exploring the catalytic function and active sites of a novelSynthetic and systems biotechnology · 2022Article
- Elucidation of the di-c-glycosylation steps during biosynthesis of the antitumor antibiotic, kidamycin.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioactive natural C-glycosides are rare and chemical C-glycosylation faces challenges while enzymatic C-glycosylation catalyzed by C-glycosyltransferases provides an alternative way. However, only a small number of C-glycosyltransferases have been found, and most of the discovered C-glycosyltransferases prefer to glycosylate phenols with an acyl side chain. Here, a promiscuous C-glycosyltransferase, AbCGT, which is capable of C-glycosylating scaffolds lacking acyl groups, is identified from Aloe barbadensis. Based on the substrate promiscuity of AbCGT, 16 C-glycosides with inhibitory activity against sodium-dependent glucose transporters 2 are chemo-enzymatically synthesized. The C-glycoside 46a shows hypoglycemic activity in diabetic mice and is biosynthesized with a cumulative yield on the 3.95 g L
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