Evidence map›Paper›PMID 33055478›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Anti-LGI1 Encephalitis Developing Immunoglobulin Responsive Orthostatic Hypotension after Remission.

Kenta Orimo, Nobue K Iwata, Mizuho Kawai, Hideki Nakajima, Katsuhiko Takeda, Hiroyuki Murai, Jun Goto

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kenta OrimoDepartment of Neurology, International University of Health and Welfare Mita Hospital, Japan.
Nobue K IwataDepartment of Neurology, International University of Health and Welfare Mita Hospital, Japan.
Mizuho KawaiDepartment of Neurology, International University of Health and Welfare Mita Hospital, Japan.
Hideki NakajimaDepartment of Neurology, International University of Health and Welfare Mita Hospital, Japan.
Katsuhiko TakedaDepartment of Neurology, International University of Health and Welfare Mita Hospital, Japan.
Hiroyuki MuraiDepartment of Neurology, International University of Health and Welfare Mita Hospital, Japan.
Jun GotoDepartment of Neurology, International University of Health and Welfare Mita Hospital, Japan.
Mita Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-leucine-rich glioma-inactivated 1 (LGI1) antibody is associated with limbic encephalitis. We herein report a patient with anti-LGI1 encephalitis who developed severe orthostatic hypotension (OH) responsive to immunoglobulin therapy five years after developing symptoms of encephalitis. A 71-year-old man presented with amnesia caused by limbic encephalitis. The symptoms of encephalitis improved partially without any immunotherapy. Five years later, he developed severe OH, and anti-LGI1 antibody was positive. The catecholamine dynamics indicated that the central autonomic nervous system was the lesion of his OH. Intravenous immunoglobulin therapy improved the OH. This case suggests that anti-LGI1 antibody can be associated with severe OH.

Indexed as

EncephalitisGliomaHypotension, OrthostaticLimbic EncephalitisPotassium Channels, Voltage-GatedAgedAutoantibodiesHumansIntracellular Signaling Peptides and ProteinsLeucineMaleAutoantibodiesIntracellular Signaling Peptides and ProteinsLeucinePotassium Channels, Voltage-Gatedautonomic dysfunctionleucine-rich glioma-inactivated 1 (LGI1)limbic encephalitisorthostatic hypotension (OH)tilt testvoltage-gated potassium channel (VGKC)

Identifiers

PMID33055478
PMCPMC8502651
OpenAlexW3093058938

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.