Evidence map›Paper›PMID 33055281›Full record

Observational studyJournal of immunology (Baltimore, Md. : 1950)2020

An Allosteric Shift in CD11c Affinity Activates a Proatherogenic State in Arrested Intermediate Monocytes.

Alfredo A Hernandez, Greg A Foster, Stephanie R Soderberg, Andrea Fernandez, Mack B Reynolds, Mable K Orser, Keith A Bailey, Jason H Rogers, Gagan D Singh, Huaizhu Wu and 2 more

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Motion Blur Microscopy.bioRxiv : the preprint server for biology · 2024
    Article
  8. Review
  9. Article
  10. CITEMORNA biology · 2022
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Alfredo A HernandezDepartment of Biomedical Engineering, University of California, Davis, Davis, CA 95616.
Greg A FosterDepartment of Biomedical Engineering, University of California, Davis, Davis, CA 95616.
Stephanie R SoderbergDepartment of Biomedical Engineering, University of California, Davis, Davis, CA 95616.
Andrea FernandezDepartment of Biomedical Engineering, University of California, Davis, Davis, CA 95616.
Mack B ReynoldsDepartment of Biomedical Engineering, University of California, Davis, Davis, CA 95616.ORCID 0000-0002-8445-3749
Mable K OrserDepartment of Biomedical Engineering, University of California, Davis, Davis, CA 95616.ORCID 0000-0002-7833-7012
Keith A BaileyDepartment of Biomedical Engineering, University of California, Davis, Davis, CA 95616.
Jason H RogersDepartment of Cardiovascular and Internal Medicine, University of California, Davis Medical Center, Sacramento, CA 95817; and.ORCID 0000-0003-3363-8070
Gagan D SinghDepartment of Cardiovascular and Internal Medicine, University of California, Davis Medical Center, Sacramento, CA 95817; and.
Huaizhu WuSection of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-6846-5531
Anthony G PasseriniDepartment of Biomedical Engineering, University of California, Davis, Davis, CA 95616.ORCID 0000-0001-8007-4672
Scott I SimonDepartment of Biomedical Engineering, University of California, Davis, Davis, CA 95616; sisimon@ucdavis.edu.ORCID 0000-0003-1186-6611
University of California, Davis · USUniversity of California Davis Medical Center · USBaylor College of Medicine · US

Funding

Outside-in Mechanotransduced Inflammatory TargetsR01AI047294 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI SIMON, SCOTT IRWIN · 1999 to 2021
$7.0M
Monocyte Activation and the Role of CD11c in obesity-linked metabolic syndromeR01HL098839 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WU, HUAIZHU · 2010 to 2019
$3.2M
Vascular Mimetics to Study Inflammation and AtherosclerosisR01HL082689 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PASSERINI, ANTHONY G., SIMON, SCOTT IRWIN · 2008 to 2016
$3.2M
Engineering the innate immune response to Staphaureus infectionR01AI129302 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEACH, J. KENT, SIMON, SCOTT IRWIN · 2017 to 2021
$1.9M
NHLBI NIH HHS R01 HL082689NHLBI NIH HHS R01 HL098839NIAID NIH HHS R01 AI047294NIAID NIH HHS R01 AI129302
6 · The paper itself

Abstract

Intermediate monocytes (iMo; CD14

Indexed as

AdultAgedAllosteric RegulationAortaCase-Control StudiesCD11c AntigenCell Culture TechniquesCell LineCell MembraneCoronary Artery DiseaseCoronary VesselsEndothelial CellsEndothelium, VascularFemaleHumansIntegrin alpha4beta1CD11c AntigenIntegrin alpha4beta1Recombinant ProteinsVascular Cell Adhesion Molecule-1

Identifiers

PMID33055281
PMCPMC7653512
OpenAlexW3092978075

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.