Evidence map›Paper›PMID 33055205›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2020

Nucleic acid oxidation is associated with biomarkers of neurodegeneration in CSF in people with HIV.

Ronald J Ellis, David J Moore, Erin E Sundermann, Robert K Heaton, Sanjay Mehta, Todd Hulgan, David Samuels, Jerel A Fields, Scott L Letendre

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. HIV-1 gp120-induced lysosomal stress responses are controlled by TRPML1 redox sensors.Redox report : communications in free radical research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ronald J EllisFrom the Departments of Neurosciences and Psychiatry, University of California (R.J.E.), San Diego; Department of Psychiatry, University of California (D.J.M., E.E.S., R.K.H.), San Diego; Department of Medicine, University of California (S.M., T.H.), San Diego; Vanderbilt University (D.S., J.A.F.), Nashville, Tennessee; and Departments of Medicine and Psychiatry, University of California (S.L.L.), San Diego. roellis@ucsd.edu.ORCID 0000-0003-4931-752X
David J MooreFrom the Departments of Neurosciences and Psychiatry, University of California (R.J.E.), San Diego; Department of Psychiatry, University of California (D.J.M., E.E.S., R.K.H.), San Diego; Department of Medicine, University of California (S.M., T.H.), San Diego; Vanderbilt University (D.S., J.A.F.), Nashville, Tennessee; and Departments of Medicine and Psychiatry, University of California (S.L.L.), San Diego.
Erin E SundermannFrom the Departments of Neurosciences and Psychiatry, University of California (R.J.E.), San Diego; Department of Psychiatry, University of California (D.J.M., E.E.S., R.K.H.), San Diego; Department of Medicine, University of California (S.M., T.H.), San Diego; Vanderbilt University (D.S., J.A.F.), Nashville, Tennessee; and Departments of Medicine and Psychiatry, University of California (S.L.L.), San Diego.
Robert K HeatonFrom the Departments of Neurosciences and Psychiatry, University of California (R.J.E.), San Diego; Department of Psychiatry, University of California (D.J.M., E.E.S., R.K.H.), San Diego; Department of Medicine, University of California (S.M., T.H.), San Diego; Vanderbilt University (D.S., J.A.F.), Nashville, Tennessee; and Departments of Medicine and Psychiatry, University of California (S.L.L.), San Diego.
Sanjay MehtaFrom the Departments of Neurosciences and Psychiatry, University of California (R.J.E.), San Diego; Department of Psychiatry, University of California (D.J.M., E.E.S., R.K.H.), San Diego; Department of Medicine, University of California (S.M., T.H.), San Diego; Vanderbilt University (D.S., J.A.F.), Nashville, Tennessee; and Departments of Medicine and Psychiatry, University of California (S.L.L.), San Diego.
Todd HulganFrom the Departments of Neurosciences and Psychiatry, University of California (R.J.E.), San Diego; Department of Psychiatry, University of California (D.J.M., E.E.S., R.K.H.), San Diego; Department of Medicine, University of California (S.M., T.H.), San Diego; Vanderbilt University (D.S., J.A.F.), Nashville, Tennessee; and Departments of Medicine and Psychiatry, University of California (S.L.L.), San Diego.
David SamuelsFrom the Departments of Neurosciences and Psychiatry, University of California (R.J.E.), San Diego; Department of Psychiatry, University of California (D.J.M., E.E.S., R.K.H.), San Diego; Department of Medicine, University of California (S.M., T.H.), San Diego; Vanderbilt University (D.S., J.A.F.), Nashville, Tennessee; and Departments of Medicine and Psychiatry, University of California (S.L.L.), San Diego.
Jerel A FieldsFrom the Departments of Neurosciences and Psychiatry, University of California (R.J.E.), San Diego; Department of Psychiatry, University of California (D.J.M., E.E.S., R.K.H.), San Diego; Department of Medicine, University of California (S.M., T.H.), San Diego; Vanderbilt University (D.S., J.A.F.), Nashville, Tennessee; and Departments of Medicine and Psychiatry, University of California (S.L.L.), San Diego.
Scott L LetendreFrom the Departments of Neurosciences and Psychiatry, University of California (R.J.E.), San Diego; Department of Psychiatry, University of California (D.J.M., E.E.S., R.K.H.), San Diego; Department of Medicine, University of California (S.M., T.H.), San Diego; Vanderbilt University (D.S., J.A.F.), Nashville, Tennessee; and Departments of Medicine and Psychiatry, University of California (S.L.L.), San Diego.
University of San Diego · US

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
Age related determinants of HAND: A 12 year follow-up of CHARTER participantsR01MH107345 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEATON, ROBERT KERNACHAN, LETENDRE, SCOTT L · 2015 to 2021
$7.9M
Mitochondrial biogenesis dysfunction in the CNS of HIV-infected individuals on antiretroviral therapyK01MH115819 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIELDS, JEREL ADAM · 2018 to 2020
$480k
CNS HIV ANTI-RETROVIRAL THERAPY EFFECTS RESEARCH /CHARTER/ -278022005-278022005N01MH022005 · NIMH · UNIVERSITY OF CA -SAN DIEGO · PI GRANT, IGOR · 2003 to 2006
–
NIMHD NIH HHS L60 MD013161NIMH NIH HHS HHSN271201000030CNIMH NIH HHS HHSN271201000036CNIMH NIH HHS K01 MH115819NIMH NIH HHS N01 MH022005NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH107345
6 · The paper itself

Abstract

objectiveTo determine whether oxidative stress in virologically suppressed people with HIV (PWH) may contribute to or result from neurodegeneration, we measured 7,8-dihydro-8-oxoguanine (8-oxo-dG), a marker of DNA damage due to oxidative stress, and markers of age-related neurodegeneration, specifically, reduced levels of CSF Aβ-42, and elevated CSF total tau and neurofilament light (NFL).

methodsThis cross-sectional study prospectively enrolled participants at 6 US centers in the CNS HIV Antiretroviral Effects Research study. Inclusion criteria included HIV+ with a plasma level of HIV RNA ≤50 copies/mL. Exclusions included significant CNS confounding conditions. Measurements of total tau and Aβ-42 were performed by bead suspension array. NFL and 8-oxo-dG were measured using ELISA.

resultsParticipants were 53 PWH, mean age 55 (±9.3) years, 19% women, and 48% non-Hispanic White. Higher 8-oxo-dG correlated with markers of AD-related neurodegeneration including lower CSF Aβ-42 (r = -0.34;

conclusionsAmong virologically suppressed PWH, nucleic acid oxidation was associated with standard CSF biomarkers of neurodegeneration. Potential sources of oxidative stress in PWH include low-level HIV replication, inflammation, mitochondrial dysfunction, and specific antiretroviral drugs. Results suggest that the higher levels of oxidative stress among PWH may play a role in neurodegeneration. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that among virologically suppressed PWH, nucleic acid oxidation is associated with standard CSF biomarkers of neurodegeneration.

Indexed as

Oxidative StressAdultAgedAmyloid beta-PeptidesBiomarkersCross-Sectional StudiesDNA DamageFemaleGuanineHIV InfectionsHumansMaleMiddle AgedNerve DegenerationNeurofilament ProteinsNucleic Acids7,8-dihydro-8-oxoguanineAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersGuanineMAPT protein, humanneurofilament protein LNeurofilament ProteinsNucleic AcidsPeptide Fragmentstau Proteins

Identifiers

PMID33055205
PMCPMC7577534
OpenAlexW3093101948

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.