ArticleIEEE transactions on bio-medical engineering2021
Transcranial Focused Ultrasound Neuromodulation of Voluntary Movement-Related Cortical Activity in Humans.
Article in IEEE transactions on bio-medical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Neuromodulation effects of low-intensity transcranial focused ultrasound in human, a systematic review focusing on motor and sensory functions.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Neuroplasticity After Stroke: Clinical Evidence and Its Implication for Effective Rehabilitation Strategies.Brain & NeuroRehabilitation · 2026Review
- Medial prefrontal cortex-targeted low-intensity focused ultrasound alleviates migraine-related allodynia and affective symptoms via modulating glutamate/GABA balance in mice.The journal of headache and pain · 2026Article
- Ultrasound-Assisted multimodal neuromodulation via nanosystems.Journal of nanobiotechnology · 2026Review
- Transcranial focused ultrasound induces source localizable cortical activation in resting state humans when applied concurrently with transcranial electric stimulation.Nature communications · 2026Article
- Transcranial Focused Ultrasound Enhances the Discriminative Power of Targeted Voluntary Motor Signals in Humans.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Parameter-Determined Effects: Advances in Transcranial Focused Ultrasound for Modulating Neural Excitation and Inhibition.Bioengineering (Basel, Switzerland) · 2025Review
- Combining non-invasive brain stimulation techniques and EEG markers analysis: an innovative approach to cognitive health in aging.GeroScience · 2025Review
- Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource.medRxiv : the preprint server for health sciences · 2025Article
- A Comprehensive Review of Low-Intensity Focused Ultrasound Parameters and Applications in Neurologic and Psychiatric Disorders.Neuromodulation : journal of the International Neuromodulation Society · 2025Review
- Improving Targeting Specificity of Transcranial Focused Ultrasound in Subject Specific Head Models Using a Random Array Transducer: A k-Wave Simulation Study.IEEE access : practical innovations, open solutions · 2025Article
- Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions.Brain sciences · 2024Review
- Transcranial focused ultrasound to V5 enhances human visual motion brain-computer interface by modulating feature-based attention.Nature communications · 2024Article
- A review of functional neuromodulation in humans using low-intensity transcranial focused ultrasound.Biomedical engineering letters · 2024Review
- Transcranial magneto-acoustic stimulation improves spatial memory and modulates hippocampal neural oscillations in a mouse model of Alzheimer's disease.Frontiers in neuroscience · 2024Article
- Excitatory-inhibitory modulation of transcranial focus ultrasound stimulation on human motor cortex.CNS neuroscience & therapeutics · 2023Article
- Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?IEEE open journal of engineering in medicine and biology · 2023Article
- Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision.Light, science & applications · 2022Article
- Transcranial ultrasound neuromodulation induces neuronal correlation change in the rat somatosensory cortex.Journal of neural engineering · 2022Article
- Non-invasive brain stimulation for osteoarthritis.Frontiers in aging neuroscience · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTranscranial focused ultrasound (tFUS) is an emerging non-invasive brain stimulation tool for safely and reversibly modulating brain circuits. The effectiveness of tFUS on human brain has been demonstrated, but how tFUS influences the human voluntary motor processing in the brain remains unclear.
methodsWe apply low-intensity tFUS to modulate the movement-related cortical potential (MRCP) originating from human subjects practicing a voluntary foot tapping task. 64-channel electroencephalograph (EEG) is recorded concurrently and further used to reconstruct the brain source activity specifically at the primary leg motor cortical area using the electrophysiological source imaging (ESI).
resultsThe ESI illustrates the ultrasound modulated MRCP source dynamics with high spatiotemporal resolutions. The MRCP source is imaged and its source profile is further evaluated for assessing the tFUS neuromodulatory effects on the voluntary MRCP. Moreover, the effect of ultrasound pulse repetition frequency (UPRF) is further assessed in modulating the MRCP. The ESI results show that tFUS significantly increases the MRCP source profile amplitude (MSPA) comparing to a sham ultrasound condition, and further, a high UPRF enhances the MSPA more than a low UPRF does.
conclusionThe present results demonstrate the neuromodulatory effects of the low-intensity tFUS on enhancing the human voluntary movement-related cortical activities evidenced through the ESI. SIGNIFICANCE: This work provides the first evidence of tFUS enhancing the human endogenous motor cortical activities through excitatory modulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.