ArticleeLife2020
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 60 citations in OpenAlex.
- A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Post-GWAS Analysis of the Shared Genetic Architecture Between COVID-19 and Coronary Artery Disease.International journal of molecular sciences · 2026Article
- How Epigenetics Bridges Genes and Environment: A Multiomics Evidence Chain in Congenital Diaphragmatic Hernia.Birth defects research · 2026Review
- Article
- Molecular and epistatic interactions between pioneer transcription factors shape nucleosome dynamics and cell differentiation.Nature communications · 2025Article
- Modeling rare genetic disease with gene-edited induced pluripotent stem cells: relevance of the starting stock line.Stem cells translational medicine · 2025Article
- Transformative Potential of Induced Pluripotent Stem Cells in Congenital Heart Disease Research and Treatment.Children (Basel, Switzerland) · 2025Review
- Article
- Pioneer factor GATA6 promotes colorectal cancer through 3D genome regulation.Science advances · 2025Article
- GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis.bioRxiv : the preprint server for biology · 2025Article
- High-throughput microRNA sequencing in the developing branchial arches suggests miR-92b-3p regulation of a cardiovascular gene network.Frontiers in genetics · 2025Article
- The Identification of a Novel Pathogenic Variant in the GATA6 Gene in a Child with Neonatal Diabetes.International journal of molecular sciences · 2024Article
- Deciphering the Landscape of GATA-Mediated Transcriptional Regulation in Gastric Cancer.Antioxidants (Basel, Switzerland) · 2024Article
- Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve.Disease models & mechanisms · 2024Article
- Gata6 functions in zebrafish endoderm to regulate late differentiating arterial pole cardiogenesis.Development (Cambridge, England) · 2024Article
- Monogenic Diabetes with GATA6 Mutations: Characterization of a Novel Family and a Comprehensive Analysis of the GATA6 Clinical and Genetics Traits.Molecular biotechnology · 2024Review
- Pioneer factors: roles and their regulation in development.Trends in genetics : TIG · 2024Review
- In-Depth Genomic Analysis: The New Challenge in Congenital Heart Disease.International journal of molecular sciences · 2024Review
- Novel pathogenic GATA6 variant associated with congenital heart disease, diabetes mellitus and necrotizing enterocolitis.Pediatric research · 2024Article
- An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract.Circulation · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 13 institutions in 4 countries.
Arun Sharma *Department of Genetics, Harvard Medical School, Boston, United States.ORCID 0000-0002-0607-5455
Lauren K Wasson *Department of Genetics, Harvard Medical School, Boston, United States.ORCID 0000-0002-5193-5215
Jon Al WillcoxDepartment of Genetics, Harvard Medical School, Boston, United States.
Sarah U MortonDepartment of Genetics, Harvard Medical School, Boston, United States.
Joshua M GorhamDepartment of Genetics, Harvard Medical School, Boston, United States.
Daniel M DeLaughterDepartment of Genetics, Harvard Medical School, Boston, United States.
Meraj NeyaziDepartment of Genetics, Harvard Medical School, Boston, United States.
Manuel SchmidDepartment of Genetics, Harvard Medical School, Boston, United States.
Radhika AgarwalDepartment of Genetics, Harvard Medical School, Boston, United States.
Min Young JangDepartment of Genetics, Harvard Medical School, Boston, United States.
Christopher N ToepferDepartment of Genetics, Harvard Medical School, Boston, United States.
Tarsha WardDepartment of Genetics, Harvard Medical School, Boston, United States.
Yuri KimDepartment of Genetics, Harvard Medical School, Boston, United States.
Alexandre C PereiraDepartment of Genetics, Harvard Medical School, Boston, United States.
Steven R DePalmaDepartment of Genetics, Harvard Medical School, Boston, United States.
Angela TaiDepartment of Genetics, Harvard Medical School, Boston, United States.
Seongwon KimDepartment of Genetics, Harvard Medical School, Boston, United States.
David ConnerDepartment of Genetics, Harvard Medical School, Boston, United States.
Daniel BernsteinDepartment of Pediatrics, Stanford University School of Medicine, Stanford, United States.
Bruce D GelbDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.
Wendy K ChungDepartment of Medicine, Columbia University Medical Center, New York, United States.
Elizabeth GoldmuntzDepartment of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0003-2936-4396
George PorterDepartment of Pediatrics, University of Rochester Medical Center, Rochester, United States.
Martin Tristani-FirouziDivision of Pediatric Cardiology, University of Utah School of Medicine, Salt Lake City, United States.
Deepak SrivastavaGladstone Institutes, San Francisco, United States.ORCID 0000-0002-3480-5953
Jonathan G SeidmanDepartment of Genetics, Harvard Medical School, Boston, United States.ORCID 0000-0002-9082-3566
Christine E SeidmanDepartment of Genetics, Harvard Medical School, Boston, United States.ORCID 0000-0001-6380-1209
Pediatric Cardiac Genomics Consortium
Harvard University · USBoston University · USBrigham and Women's Hospital · USCedars-Sinai Medical Center · USCentre for Human Genetics · GBColumbia University Irving Medical Center · USGladstone Institutes · USHoward Hughes Medical Institute · USIcahn School of Medicine at Mount Sinai · USStanford University · USUniversity of Pennsylvania · USUniversity of Rochester Medical Center · USUniversity of Utah · US
Funding
NHLBI Pediatric Translational Consortium Administrative Coordinating CenterU01HL098188 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI HAMZA, TAYE, MILLER, JULIE ELAINE · 2009 to 2015
$41.3MCARDIOGENESIS--MOLECULAR MECHANISMSR01HL057181 · NHLBI · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI DEEPAK SRIVASTAVA · 1997 to 2026
$14.0MMapping Transcriptional Networks in Cardiac DevelopmentU01HL098166 · NHLBI · HARVARD MEDICAL SCHOOL · PI SEIDMAN, JONATHAN G · 2009 to 2014
$9.5MDefining Pathways from Gene Mutation to Heart FailureR01HL080494 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CHEN, CHRISTOPHER S, SEIDMAN, CHRISTINE E · 2005 to 2024
$9.4MGenomic Effects on Right Ventricular Function, Clinical Features and Outcomes in CHDU01HL098147 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI NEWBURGER, JANE W., ROBERTS, AMY E · 2009 to 2024
$6.7MGenetic determinants of human heterotaxy and aortic arch malformationU01HL098162 · NHLBI · YALE UNIVERSITY · PI BRUECKNER, MARTINA, GRUBER, PETER J · 2009 to 2024
$5.9MTraining in Advanced Heart Disease ResearchT32HL116273 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Joshua I Goldhaber, EDUARDO MARBAN · 2013 to 2026
$5.6MRegulation of Cardiac Development in Health and DiseaseUM1HL098166 · NHLBI · HARVARD MEDICAL SCHOOL · PI PENNACCHIO, LEN ALEXANDER, PU, WILLIAM TSWENCHING · 2015 to 2019
$4.4MThe Genetic Basis of Conotruncal DefectsU01HL098153 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI GOLDMUNTZ, ELIZABETH · 2009 to 2014
$4.3MGenomic studies of secundum atrial septal defectsU01HL098123 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GELB, BRUCE D · 2009 to 2014
$4.1MMolecular approaches to gene identification in congenital heart diseaseU01HL098163 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHUNG, WENDY K, WARBURTON, DOROTHY P. · 2009 to 2014
$3.9MGenetics of Hypoplastic Left Heart SyndromeUM1HL128761 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BERNSTEIN, DANIEL, SRIVASTAVA, DEEPAK · 2015 to 2019
$2.5MHoward Hughes Medical InstituteNational Science Foundation EEC-1647837NHLBI NIH HHS R01 HL057181NHLBI NIH HHS R01 HL080494NHLBI NIH HHS T32 HL116273NHLBI NIH HHS U01 HL098123NHLBI NIH HHS U01 HL098147NHLBI NIH HHS U01 HL098153NHLBI NIH HHS U01 HL098162NHLBI NIH HHS U01 HL098163NHLBI NIH HHS U01 HL098166NHLBI NIH HHS U01 HL098188NHLBI NIH HHS U01 HL153009NHLBI NIH HHS UM1 HL098166NHLBI NIH HHS UM1 HL128711NHLBI NIH HHS UM1 HL128761NIH HHS UM1HL128711Wellcome Trust
Abstract
Damaging
Indexed as
Cell DifferentiationDiaphragmEpigenesis, GeneticGATA6 Transcription FactorGene Expression ProfilingHeartHumansInduced Pluripotent Stem CellsMutation, MissenseMyocytes, CardiacPancreasGATA6 protein, humanGATA6 Transcription FactorCRISPRdevelopmentdevelopmental biologygene mutationhearthumaniPSCregenerative medicinestem cells
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.