Evidence map›Paper›PMID 33054904›Full record

ArticleThe Journal of general virology2021

Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell-cell fusion.

Nazia Thakur, Carina Conceicao, Ariel Isaacs, Stacey Human, Naphak Modhiran, Rebecca K McLean, Miriam Pedrera, Tiong Kit Tan, Pramila Rijal, Alain Townsend and 6 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of general virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

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  11. FeMV is a cathepsin-dependent unique morbillivirus infecting the kidneys of domestic cats.Proceedings of the National Academy of Sciences of the United States of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Nazia ThakurThe Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Carina ConceicaoThe Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Ariel IsaacsUniversity of Queensland, Brisbane, Queensland 4071, Australia.
Stacey HumanThe Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Naphak ModhiranUniversity of Queensland, Brisbane, Queensland 4071, Australia.
Rebecca K McLeanThe Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Miriam PedreraThe Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Tiong Kit TanMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Pramila RijalMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Alain TownsendMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Geraldine TaylorThe Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Paul R YoungUniversity of Queensland, Brisbane, Queensland 4071, Australia.
Daniel WattersonUniversity of Queensland, Brisbane, Queensland 4071, Australia.
Keith J ChappellUniversity of Queensland, Brisbane, Queensland 4071, Australia.
Simon P GrahamThe Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Dalan BaileyThe Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
The Pirbright Institute · GBThe University of Queensland · AUUniversity of Oxford · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/I/00007031Biotechnology and Biological Sciences Research Council BBS/E/I/00007034Biotechnology and Biological Sciences Research Council BBS/E/I/00007038Biotechnology and Biological Sciences Research Council BBS/E/I/00007039Biotechnology and Biological Sciences Research Council BBS/E/I/COV07001Medical Research Council MR/P021735/1
6 · The paper itself

Abstract

Although enveloped viruses canonically mediate particle entry through virus-cell fusion, certain viruses can spread by cell-cell fusion, brought about by receptor engagement and triggering of membrane-bound, viral-encoded fusion proteins on the surface of cells. The formation of pathogenic syncytia or multinucleated cells is seen

Indexed as

High-Throughput Screening AssaysAnimalsAntibodies, NeutralizingAntibodies, ViralCell FusionConvalescenceCOVID-19Genes, ReporterGreen Fluorescent ProteinsHEK293 CellsHenipavirus InfectionsHumansImmune SeraLuciferasesModels, MolecularNipah VirusAntibodies, NeutralizingAntibodies, ViralGreen Fluorescent ProteinsImmune SeraLuciferasesViral Fusion Protein InhibitorsViral Fusion Proteinscell–cell fusionenveloped virusmFITneutralizing antibodiesNipah virusRSVSARS-CoVSARS-CoV-2vaccines

Identifiers

PMID33054904
PMCPMC8116787
OpenAlexW3093472344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.