ArticleBMC biology2020
Spatial and temporal modulation of enterotoxigenic E. coli H10407 pathogenesis and interplay with microbiota in human gut models.
Article in BMC biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Small intestinal microbiome, the underrated maestro of SIMO disease.FEMS microbiology reviews · 2026Review
- Small intestine is not colon: a newGut microbes · 2025Article
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- Exploring the impact of digestive physicochemical parameters of adults and infants on the pathophysiology of Cryptosporidium parvum using the dynamic TIM-1 gastrointestinal model.Gut pathogens · 2024Article
- Review
- Supplementation with a cranberry extract favors the establishment of butyrogenic guilds in the human fermentation SHIME system.Microbiome research reports · 2024Article
- Characterization of the Interindividual Variability Associated with the Microbial Metabolism of (-)-Epicatechin.Journal of agricultural and food chemistry · 2023Article
- Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration.Cell reports. Medicine · 2023Review
- Effects of supplementation ofFrontiers in microbiology · 2023Article
- Characterization of Intestinal Microbiota in Lambs with Different Susceptibility toVeterinary sciences · 2022Article
- UPEC Colonic-Virulence and Urovirulence Are Blunted by Proanthocyanidins-Rich Cranberry Extract Microbial Metabolites in a Gut Model and a 3D Tissue-Engineered Urothelium.Microbiology spectrum · 2022Article
- Role of mucus-bacteria interactions in Enterotoxigenic Escherichia coli (ETEC) H10407 virulence and interplay with human microbiome.NPJ biofilms and microbiomes · 2022Article
- Article
- Development of a reproducible small intestinal microbiota model and its integration into the SHIMEFrontiers in microbiology · 2022Article
- Article
- Enrofloxacin Promotes Plasmid-Mediated Conjugation Transfer of Fluoroquinolone-Resistance GeneFrontiers in microbiology · 2021Article
- Current and Future Perspectives on the Role of Probiotics, Prebiotics, and Synbiotics in Controlling PathogenicFrontiers in microbiology · 2021Review
- Phage lysins for intestinal microbiome modulation: current challenges and enabling techniques.Gut microbesReview
- Multi-targeted properties of the probioticGut microbesArticle
- Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnterotoxigenic Escherichia coli (ETEC) substantially contributes to the burden of diarrheal illnesses in developing countries. With the use of complementary in vitro models of the human digestive environment, TNO gastrointestinal model (TIM-1), and Mucosal Simulator of the Human Intestinal Microbial Ecosystem (M-SHIME), we provided the first detailed report on the spatial-temporal modulation of ETEC H10407 survival, virulence, and its interplay with gut microbiota. These systems integrate the main physicochemical parameters of the human upper digestion (TIM-1) and simulate the ileum vs ascending colon microbial communities and luminal vs mucosal microenvironments, captured from six fecal donors (M-SHIME).
resultsA loss of ETEC viability was noticed upon gastric digestion, while a growth renewal was found at the end of jejunal and ileal digestion. The remarkable ETEC mucosal attachment helped to maintain luminal concentrations above 6 log
conclusionsThis study provides a better understanding of the interplay between ETEC and gastrointestinal cues and may serve to complete knowledge on ETEC pathogenesis and inspire novel prophylactic strategies for diarrheal diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.