ArticleThe journal of physiological sciences : JPS2020
The relationship between olfaction and cognitive function in the elderly.
Article in The journal of physiological sciences : JPS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Assessment and behavioural management options for older adults with declined smell and taste functions: a scoping review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Olfactory Network Functional Connectivity as a Marker for Parkinson's Disease Severity.Life (Basel, Switzerland) · 2025Article
- Olfactory Dysfunction as a Clinical Marker of Early Glymphatic Failure in Neurodegenerative Diseases.Diagnostics (Basel, Switzerland) · 2025Review
- Comparative EEG study of neurodynamics upon olfactory stimulation in COVID-19 patients.Frontiers in human neuroscience · 2025Article
- Olfactory Identification as a Biomarker for Cognitive Impairment: Insights from Healthy Aging, Subjective Cognitive Decline, and Mild Cognitive Impairment.European journal of investigation in health, psychology and education · 2024Article
- Influence of age on nicotinic cholinergic regulation of blood flow in rat's olfactory bulb and neocortex.The journal of physiological sciences : JPS · 2024Review
- Beyond anosmia: olfactory dysfunction as a common denominator in neurodegenerative and neurodevelopmental disorders.Frontiers in neuroscience · 2024Review
- Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats.The journal of physiological sciences : JPS · 2023Article
- Associations of Olfaction With Longitudinal Trajectories of Brain Volumes and Neuropsychological Function in Older Adults.Neurology · 2023Article
- How the sense of smell influences cognition throughout life.Neuroforum · 2022Review
- Olfactory function and discrimination ability in the elderly: a pilot study.The journal of physiological sciences : JPS · 2022Article
- Normative Data of the Trail Making Test Among Urban Community-Dwelling Older Adults in Japan.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the relationship between olfaction and cognitive function in 12 elderly people (age: 80.9 ± 1.6) living in the community. Olfactory function was assessed by the identification threshold for rose odor. Four cognitive measures consisting general cognitive ability assessed by Mini-Mental State Examination (MMSE), its sub-domains, and attentional ability assessed by drawing a line to connect the numbers consecutively (trail-making test part A; TMT-A), were assessed. Subjects with a higher olfactory threshold (≥ 5) declined more in the performance speed of TMT-A (73% ± 7%, p = 0.05) compared with those subjects with a lower threshold (≤ 4) (averaged value was set at 100%). Other cognitive statuses assessed by MMSE tended to decline in subjects with higher thresholds. Because attentional function relates to the basal forebrain cholinergic system, our results suggest that olfactory impairment links to the decline in cognitive function, particularly of attention-relating cholinergic function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.