Evidence map›Paper›PMID 33054397›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity Contributes to Adipose Tissue inflammation.

Gamze B Bulut, Gabriel F Alencar, Katherine M Owsiany, Anh T Nguyen, Santosh Karnewar, Ryan M Haskins, Lillian K Waller, Olga A Cherepanova, Rebecca A Deaton, Laura S Shankman and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Review
  8. Review
  9. Nobody Is Perfect: Cre Drivers Deserve Careful Consideration.Arteriosclerosis, thrombosis, and vascular biology · 2023
    Article
  10. Article
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  12. Article
  13. "Cre"ating New Tools for Smooth Muscle Analysis.Arteriosclerosis, thrombosis, and vascular biology · 2023
    Article
  14. A New AutosomalArteriosclerosis, thrombosis, and vascular biology · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Quantitative Methods to Assess Adipose Vasculature.Methods in molecular biology (Clifton, N.J.) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Gamze B BulutThe Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville (G.B.B., G.F.A., K.M.O., A.T.N., S.K., R.M.H., L.K.W., R.A.D., L.S.S., G.K.O.).
Gabriel F AlencarThe Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville (G.B.B., G.F.A., K.M.O., A.T.N., S.K., R.M.H., L.K.W., R.A.D., L.S.S., G.K.O.).
Katherine M OwsianyThe Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville (G.B.B., G.F.A., K.M.O., A.T.N., S.K., R.M.H., L.K.W., R.A.D., L.S.S., G.K.O.).
Anh T NguyenThe Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville (G.B.B., G.F.A., K.M.O., A.T.N., S.K., R.M.H., L.K.W., R.A.D., L.S.S., G.K.O.).
Santosh KarnewarThe Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville (G.B.B., G.F.A., K.M.O., A.T.N., S.K., R.M.H., L.K.W., R.A.D., L.S.S., G.K.O.).
Ryan M HaskinsThe Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville (G.B.B., G.F.A., K.M.O., A.T.N., S.K., R.M.H., L.K.W., R.A.D., L.S.S., G.K.O.).
Lillian K WallerThe Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville (G.B.B., G.F.A., K.M.O., A.T.N., S.K., R.M.H., L.K.W., R.A.D., L.S.S., G.K.O.).
Olga A CherepanovaCardiovascular and Metabolic Sciences Lerner Research Institute, Cleveland Clinic, OH (O.A.C.).
Rebecca A DeatonThe Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville (G.B.B., G.F.A., K.M.O., A.T.N., S.K., R.M.H., L.K.W., R.A.D., L.S.S., G.K.O.).
Laura S ShankmanThe Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville (G.B.B., G.F.A., K.M.O., A.T.N., S.K., R.M.H., L.K.W., R.A.D., L.S.S., G.K.O.).
Susanna R KellerDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia, Charlottesville (S.R.K.).
Gary K OwensThe Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville (G.B.B., G.F.A., K.M.O., A.T.N., S.K., R.M.H., L.K.W., R.A.D., L.S.S., G.K.O.).
Norwegian Womens Public Health Association · NODr. M.G.R. Educational and Research Institute · INCleveland Clinic Lerner College of Medicine · USUniversity of Virginia · US

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
IL1beta signaling in SMCpromotes beneficial changes in late stage atherosclerotic lesion pathogenesisR01HL141425 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2019 to 2022
$3.1M
Oct4 and Klf4 regulate microvascular SMC-pericyte plasticity, angiogenesis, and metabolic dysfunctionR01HL135018 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2017 to 2020
$3.1M
Defining SMC phenotypes critical in late stage atherosclerosis pathogenesisR01HL136314 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2018 to 2021
$3.0M
PDGFbeta Receptor Activation Promotes Atheroprotective Changes in SMC PhenotypeR01HL132904 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2017 to 2020
$2.6M
NHLBI NIH HHS R01 HL132904NHLBI NIH HHS R01 HL135018NHLBI NIH HHS R01 HL136314NHLBI NIH HHS R01 HL141425NHLBI NIH HHS T32 HL007284
6 · The paper itself

Abstract

objectiveSmooth muscle cells and pericytes display remarkable plasticity during injury and disease progression. Here, we tested the hypothesis that perivascular cells give rise to

conclusionsPerivascular cells within the AT microvasculature dynamically respond to DIO and modulate tissue inflammation and metabolism in a KLF4-dependent manner.

Indexed as

Cell PlasticityAdipose TissueAnimalsBlood GlucoseCell LineageDiet, High-FatDisease Models, AnimalEndothelial CellsInflammation MediatorsInsulin ResistanceKruppel-Like Factor 4Kruppel-Like Transcription FactorsMacrophagesMaleMiceMice, KnockoutBlood GlucoseInflammation MediatorsKlf4 protein, mouseKruppel-Like Factor 4Kruppel-Like Transcription Factorsinflammationmacrophagemiceobesitypericyte

Identifiers

PMID33054397
PMCPMC7769966
OpenAlexW3092905438

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.