Evidence map›Paper›PMID 33054193›Full record

ArticleJournal of medicinal chemistry2020

Design, Synthesis, and Pharmacological Evaluation of Analogues Derived from the PLEV Tetrapeptide as Protein-Protein Interaction Modulators of Voltage-Gated Sodium Channel 1.6.

Pingyuan Wang, Paul A Wadsworth, Nolan M Dvorak, Aditya K Singh, Haiying Chen, Zhiqing Liu, Richard Zhou, Luis Marcelo F Holthauzen, Jia Zhou, Fernanda Laezza

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Inhibition of the GSK3β/Nav1.6 complex suppresses early-stage Alzheimer's hyperexcitability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  5. Article
  6. Article
  7. Inhibition of the Akt/PKB Kinase Increases NaInternational journal of molecular sciences · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Development of Allosteric Modulators of Voltage-Gated NaCurrent topics in medicinal chemistry · 2021
    Review
  12. Differential Modulation of the Voltage-Gated NaFrontiers in molecular biosciences · 2021
    Article
  13. Context dependent roles of FGF13B-NaNeurobiology of pain (Cambridge, Mass.)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Pingyuan Wang
Paul A Wadsworth
Nolan M Dvorak
Aditya K Singh
Haiying Chen
Richard Zhou
Luis Marcelo F Holthauzen
Fernanda Laezza
The University of Texas Medical Branch at Galveston · US

Funding

HOUSTON AREA MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008280 · NIGMS · RICE UNIVERSITY · PI WENSEL, THEODORE G · 1988 to 2023
$8.0M
Neurotrophin-dependent regulation of voltage-gated sodium channelsR01MH124351 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2020 to 2024
$3.0M
Validation of FGF14 as a New Molecular Target of GSK3R01MH095995 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2012 to 2016
$1.9M
Discovery of Chemical Probes for Psychiatric Disorders and AddictionR01MH111107 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA, ZHOU, JIA · 2016 to 2018
$1.6M
Core Center for Translational Addiction SciencesP30DA028821 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CUNNINGHAM, KATHRYN A. · 2009 to 2010
$1.5M
Clinical and Behavioral Science Training in Aging and Health DisparitiesT32AG051131 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MARKIDES, KYRIAKOS S · 2015 to 2019
$436k
Malvern MicroCal PEAQ Isothermal Titration CalorimeterS10OD023576 · OD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI RAJARATHNAM, KRISHNA · 2017 to 2017
$120k
NIA NIH HHS T32 AG051131NIDA NIH HHS P30 DA028821NIGMS NIH HHS T32 GM008280NIH HHS S10 OD023576NIMH NIH HHS R01 MH095995NIMH NIH HHS R01 MH111107NIMH NIH HHS R01 MH124351
6 · The paper itself

Abstract

The voltage-gated Na

Indexed as

Drug DesignFibroblast Growth FactorsGenetic Complementation TestHEK293 CellsHumansIon Channel GatingLigandsLuciferasesMolecular Docking SimulationNAV1.6 Voltage-Gated Sodium ChannelNeuronsOligopeptidesPatch-Clamp TechniquesPeptidomimeticsProtein BindingStructure-Activity Relationshipfibroblast growth factor 14Fibroblast Growth FactorsLigandsLuciferasesNAV1.6 Voltage-Gated Sodium ChannelOligopeptidesPeptidomimetics

Identifiers

PMID33054193
PMCPMC8317200
OpenAlexW3093155940

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.