Evidence map›Paper›PMID 33053948›Full record

SynthesisJournal of stroke2020

Stroke in Coronavirus Disease 2019: A Systematic Review.

Rohit Bhatia, Radhakrishna Pedapati, Snigdha Komakula, M V Padma Srivastava, Sreenivas Vishnubhatla, Dheeraj Khurana

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Stroke and COVID-19: An Umbrella Review.Archives of academic emergency medicine · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. COVID-19 independently predicts poor outcomes in Acute Ischemic Stroke- Insights from a multicenter study from Pakistan and United Arab Emirates.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023
    Article
  12. Review
  13. Review
  14. New-onset acute ischemic stroke following COVID-19: A case-control study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rohit BhatiaDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Radhakrishna PedapatiDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Snigdha KomakulaDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
M V Padma SrivastavaDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Sreenivas VishnubhatlaDepartment of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Dheeraj KhuranaDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeVarious neurological findings including stroke in patients with coronavirus disease 2019 (COVID-19) have been described, although no clarity exists regarding the nature and pattern of this association. This systematic review aims to report the characteristics of stroke in patients with COVID-19.

methodsThree authors independently searched Web of Science, Embase, Scopus, and PubMed starting from inception up to May 22, 2020. The data for individual patients was extracted where available from published reports including clinical and laboratory parameters and analysed for any significant associations between variables.

resultsWe identified 30 relevant articles involving 115 patients with acute or subacute stroke with COVID-19. The mean±standard deviation age was 62.5±14.5 years. Stroke was ischemic in majority of the patients (101 [87.8%]). Hypertension (42 [42%]), dyslipidaemia (24 [26.1%]), and diabetes (23 [23.2%]) were the major vascular risk factors. Most of the patients (80 [85.1%]) had COVID-19 symptoms at the time of stroke with a median interval of 10 days to stroke from the diagnosis of COVID-19. Three-fourths (86 [74.8%]) of the patients were critically ill which frequently delayed the diagnosis of stroke. High levels of D-dimer, and ferritin were observed in these patients. Patients with COVID-19 and stroke had a high mortality (47.9%). Factors associated with mortality were intensive care unit admission, having two or more vascular risk factors, particularly smoking and high levels of D-dimer, C-reactive protein, and lactate dehydrogenase.

conclusionsThe association between stroke and COVID-19 is probably multifactorial including an amalgamation of traditional vascular risk factors, proinflammatory and a prothrombotic state. Prospectively collected data is required in the future to confirm this hypothesis.

Indexed as

Clinical trialCOVID-19Severe acute respiratory syndrome coronavirus 2StrokeSystematic reviewVirus diseases

Identifiers

PMID33053948
PMCPMC7568983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.