Evidence map›Paper›PMID 33053866›Full record

ArticleCancers2020

No Impact of Smoking Status on Breast Cancer Tumor Infiltrating Lymphocytes, Response to Neoadjuvant Chemotherapy and Prognosis.

Vanille Simon, Lucie Laot, Enora Laas, Sonia Rozette, Julien Guerin, Thomas Balezeau, Marion Nicolas, Jean-Yves Pierga, Florence Coussy, Marick Laé and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Vanille SimonDepartment of Surgical Oncology, Institut Curie, University Paris, 75005 Paris, France.
Lucie LaotDepartment of Surgical Oncology, Institut Curie, University Paris, 75005 Paris, France.
Enora LaasDepartment of Surgical Oncology, Institut Curie, University Paris, 75005 Paris, France.
Sonia RozetteDepartment of Medical Oncology, Institut Curie, University Paris, 75005 Paris, France.
Julien GuerinData Factory, Data Office, Institut Curie, 25 rue d'Ulm, 75005 Paris, France.ORCID 0000-0002-3024-8483
Thomas BalezeauData Factory, Data Office, Institut Curie, 25 rue d'Ulm, 75005 Paris, France.
Marion NicolasDepartment of Surgical Oncology, Institut Curie, University Paris, 75005 Paris, France.
Jean-Yves PiergaDepartment of Medical Oncology, Institut Curie, University Paris, 75005 Paris, France.
Florence CoussyDepartment of Medical Oncology, Institut Curie, University Paris, 75005 Paris, France.
Marick LaéDepartment of Tumor Biology, Institut Curie, 75005 Paris, France.
Diane De CrozeDepartment of Tumor Biology, Institut Curie, 75005 Paris, France.
Beatriz GrandalDepartment of Surgical Oncology, Institut Curie, University Paris, 75005 Paris, France.
Judith AbecassisResidual Tumor & Response to Treatment Laboratory, RT2Lab, Translational Research Department, INSERM, U932 Immunity and Cancer, University Paris, 75005 Paris, France.
Elise DumasResidual Tumor & Response to Treatment Laboratory, RT2Lab, Translational Research Department, INSERM, U932 Immunity and Cancer, University Paris, 75005 Paris, France.
Florence LereboursDepartment of Medical Oncology, Institut Curie, University Paris, 75005 Paris, France.
Fabien ReyalDepartment of Surgical Oncology, Institut Curie, University Paris, 75005 Paris, France.
Anne-Sophie HamyDepartment of Medical Oncology, Institut Curie, University Paris, 75005 Paris, France.
Institut Curie · FRInserm · FR

Funding

Site de Recherche Integrée en Cancérologie/Institut 315 National du Cancer INCa-DGOS-4654
6 · The paper itself

Abstract

Tobacco use is associated with an increase in breast cancer (BC) mortality. Pathologic complete response (pCR) rate to neoadjuvant chemotherapy (NAC) is influenced by tumor-infiltrating lymphocyte (TIL) levels and is associated with a better long-term survival outcome. The aim of our study is to evaluate the impact of smoking status on TIL levels, response to NAC and prognosis for BC patients. We retrospectively evaluated pre- and post-NAC stromal and intra tumoral TIL levels and pCR rates on a cohort of T1-T3NxM0 BC patients treated with NAC between 2002 and 2012 at Institut Curie. Smoking status (current, ever, never smokers) was collected in clinical records. We analyzed the association between smoking status, TIL levels, pCR rates and survival outcomes among the whole population, and according to BC subtype. Nine hundred and fifty-six BC patients with available smoking status information were included in our analysis (current smokers,

Indexed as

breast cancerneoadjuvant chemotherapypathologic complete responseprognosissmoking statustumor infiltrating lymphocytes

Identifiers

PMID33053866
PMCPMC7601636
OpenAlexW3092646197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.