Evidence map›Paper›PMID 33053834›Full record

ArticleInternational journal of molecular sciences2020

All-Atomic Molecular Dynamic Studies of Human and

Wu Xu, Xiao-Jun Xie, Ali K Faust, Mengmeng Liu, Xiao Li, Feng Chen, Ashlin A Naquin, Avery C Walton, Peter W Kishbaugh, Jun-Yuan Ji

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Wu XuDepartment of Chemistry, University of Louisiana at Lafayette, P.O. Box 44370, Lafayette, LA 70504, USA.ORCID 0000-0002-2982-3276
Xiao-Jun XieDepartment of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, 8447 Riverside Parkway, Bryan, TX 77807, USA.ORCID 0000-0001-7768-1586
Ali K FaustDepartment of Chemistry, University of Louisiana at Lafayette, P.O. Box 44370, Lafayette, LA 70504, USA.
Mengmeng LiuDepartment of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, 8447 Riverside Parkway, Bryan, TX 77807, USA.
Xiao LiDepartment of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, 8447 Riverside Parkway, Bryan, TX 77807, USA.
Feng ChenHigh Performance Computing, 329 Frey Computing Services Center, Louisiana State University, Baton Rouge, LA 70803, USA.
Ashlin A NaquinDepartment of Chemistry, University of Louisiana at Lafayette, P.O. Box 44370, Lafayette, LA 70504, USA.
Avery C WaltonDepartment of Chemistry, University of Louisiana at Lafayette, P.O. Box 44370, Lafayette, LA 70504, USA.
Peter W KishbaughDepartment of Chemistry, University of Louisiana at Lafayette, P.O. Box 44370, Lafayette, LA 70504, USA.
Jun-Yuan JiDepartment of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, 8447 Riverside Parkway, Bryan, TX 77807, USA.ORCID 0000-0002-4483-4336
University of Louisiana at Lafayette · USTexas A&M Health Science Center · USLouisiana State University · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Context-specific Functions of CDK8R01GM133011 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI JI, JUN-YUAN · 2020 to 2023
$1.3M
Louisiana Board of Regents LEQSF(2017-18)-ENH-TR-31NIGMS NIH HHS R01 GM133011NIH HHS GM133011NIH HHS P40 OD018537
6 · The paper itself

Abstract

Cyclin-dependent kinase 8 (CDK8) and its regulatory partner Cyclin C (CycC) play conserved roles in modulating RNA polymerase II (Pol II)-dependent gene expression. To understand the structure and function relations of CDK8, we analyzed the structures of human and

Indexed as

Amino Acid MotifsBinding SitesModels, MolecularProtein Interaction Domains and MotifsAmino Acid SequenceAmino Acid SubstitutionAnimalsCyclin-Dependent Kinase 8Drosophila ProteinsHumansHydrogen BondingLigandsMolecular ConformationMutationProtein BindingProtein Kinase InhibitorsCdk8 protein, DrosophilaCDK8 protein, humanCyclin-Dependent Kinase 8Drosophila ProteinsLigandsProtein Kinase InhibitorsCDK8drug binding sitekinase domainLXXLL motifmolecular dynamics simulationstructure

Identifiers

PMID33053834
PMCPMC7590003
OpenAlexW3092574269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.