Evidence map›Paper›PMID 33053825›Full record

ArticlePharmaceuticals (Basel, Switzerland)2020

Nawraj Rummun, Philippe Rondeau, Emmanuel Bourdon, Elisabete Pires, James McCullagh, Timothy D W Claridge, Theeshan Bahorun, Wen-Wu Li, Vidushi S Neergheen

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Novel assay to measure chromosome instability identifiesFrontiers in bioengineering and biotechnology · 2022
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Nawraj RummunDepartment of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit 80837, Mauritius.
Philippe RondeauUniversité de La Réunion, INSERM, UMR 1188 Diabète athérothrombose Thérapies Réunion Océan Indien (DéTROI), Saint-Denis de La Réunion, 97490 Sainte-Clotilde, Reunion, France.
Emmanuel BourdonUniversité de La Réunion, INSERM, UMR 1188 Diabète athérothrombose Thérapies Réunion Océan Indien (DéTROI), Saint-Denis de La Réunion, 97490 Sainte-Clotilde, Reunion, France.ORCID 0000-0003-3731-150X
Elisabete PiresChemical Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.
James McCullaghChemical Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.
Timothy D W ClaridgeChemical Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.
Theeshan BahorunBiopharmaceutical Unit Centre for Biomedical and Biomaterials Research, MSIRI Building, University of Mauritius, Réduit 80837, Mauritius.ORCID 0000-0002-8099-9090
Wen-Wu LiSchool of Pharmacy and Bioengineering, Faculty of Medicine and Health Sciences, Keele University, Thornburrow Drive, Stoke on Trent ST4 7QB, UK.ORCID 0000-0002-3706-6068
Vidushi S NeergheenDepartment of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit 80837, Mauritius.
Mauritius Sugarcane Industry Research Institute · MUUniversity of Oxford · GBInserm · FRKeele University · GB

Funding

The Royal Society IE160622
6 · The paper itself

Abstract

Tropical forests constitute a prolific sanctuary of unique floral diversity and potential medicinal sources, however, many of them remain unexplored. The scarcity of rigorous scientific data on the surviving Mascarene endemic taxa renders bioprospecting of this untapped resource of utmost importance. Thus, in view of valorizing the native resource, this study has as its objective to investigate the bioactivities of endemic leaf extracts. Herein, seven Mascarene endemic plants leaves were extracted and evaluated for their in vitro antioxidant properties and antiproliferative effects on a panel of cancer cell lines, using methyl thiazolyl diphenyl-tetrazolium bromide (MTT) and clonogenic cell survival assays. Flow cytometry and comet assay were used to investigate the cell cycle and DNA damaging effects, respectively. Bioassay guided-fractionation coupled with liquid chromatography mass spectrometry (MS), gas chromatography-MS, and nuclear magnetic resonance spectroscopic analysis were used to identify the bioactive compounds. Among the seven plants tested,

Indexed as

antioxidantbioassay-guided fractionationcancercell cycle arrestcytotoxicityMascarene endemicphenolicsTerminalia bentzoë

Identifiers

PMID33053825
PMCPMC7650599
OpenAlexW3092124096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.