ArticleJournal of clinical medicine2020
Skin Manifestations in COVID-19: Prevalence and Relationship with Disease Severity.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Prevalence of skin manifestations in patients with COVID-19: a systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.The Cochrane database of systematic reviews · 2022Pooled it
- Are the chilblain-like lesions observed during the COVID-19 pandemic due to severe acute respiratory syndrome coronavirus 2? Systematic review and meta-analysis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Pooled it
- Skin Manifestations in COVID-19 Patients: Are They Indicators for Disease Severity? A Systematic Review.Frontiers in medicine · 2021Pooled it
- Diagnosis and management of COVID toes in outpatients: a case report.Journal of medical case reports · 2024Article
- Article
- Emerging role of complement in COVID-19 and other respiratory virus diseases.Cellular and molecular life sciences : CMLS · 2024Review
- Cutaneous manifestations associated with COVID-19 infection at a university hospital in eastern China.American journal of clinical and experimental immunology · 2024Article
- Review
- Molecular evidence for SARS-CoV-2 in samples collected from patients with morbilliform eruptions since late 2019 in Lombardy, northern Italy.Environmental research · 2022Article
- Pathobiology of Cutaneous Manifestations Associated with COVID-19 and Their Management.Viruses · 2022Review
- Characteristics of herpes zoster infection in patients with COVID-19: a systematic scoping review.International journal of dermatology · 2022Article
- The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review.Dermatopathology (Basel, Switzerland) · 2022Review
- Article
- Dermatological manifestations associated with COVID-19: A comprehensive review of the current knowledge.Journal of medical virology · 2021Review
- The COVID rash that puts the 'U' in GROUCH!Proceedings (Baylor University. Medical Center) · 2021Article
- Time of Onset of Selected Skin Lesions Associated with COVID-19: A Systematic Review.Dermatology and therapy · 2021Review
- Clinical Manifestations of COVID-19 in the Feet: A Review of Reviews.Journal of clinical medicine · 2021Review
- Lack of skin manifestations in COVID-19 hospitalized patients during the second epidemic wave in Spain: a possible association with a novel SARS-CoV-2 variant - a cross-sectional study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021Article
Corrections and comments
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Authors and funding
25 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData on the clinical patterns and histopathology of SARS-CoV-2 related skin lesions, as well as on their relationship with the severity of COVID-19 are limited. METHODS AND MATERIALS: Retrospective analysis of a prospectively collected cohort of patients with SARS-CoV-2 infection in a teaching hospital in Barcelona, Spain, from 1 April to 1 May 2020. Clinical, microbiological and therapeutic characteristics, clinicopathological patterns of skin lesions, and direct immunofluorescence and immunohistochemical findings in skin biopsies were analyzed.
resultsFifty-eight out of the 2761 patients (2.1%) either consulting to the emergency room or admitted to the hospital for COVID-19 suspicion during the study period presented COVID-19 related skin lesions. Cutaneous lesions could be categorized into six patterns represented by the acronym "GROUCH": Generalized maculo-papular (20.7%), Grover's disease and other papulo-vesicular eruptions (13.8%), livedo Reticularis (6.9%), Other eruptions (22.4%), Urticarial (6.9%), and CHilblain-like (29.3%). Skin biopsies were performed in 72.4%, including direct immunofluorescence in 71.4% and immunohistochemistry in 28.6%. Patients with chilblain-like lesions exhibited a characteristic histology and were significantly younger and presented lower rates of systemic symptoms, radiological lung infiltrates and analytical abnormalities, and hospital and ICU admission compared to the rest of patients.
conclusionCutaneous lesions in patients with COVID-19 appear to be relatively rare and varied. Patients with chilblain-like lesions have a characteristic clinicopathological pattern and a less severe presentation of COVID-19.
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