SynthesisNutrients2020
The Effect of Perioperative Vitamin C on Postoperative Analgesic Consumption: A Meta-Analysis of Randomized Controlled Trials.
Synthesis in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Vitamin deficiency, a neglected risk factor for post-anesthesia complications: a systematic review.European journal of medical research · 2025Pooled it
- Analgesic efficacy and risk of low-to-medium dose intrathecal morphine in patients undergoing cardiac surgery: An updated meta-analysis.Frontiers in medicine · 2022Pooled it
- Effect of Vitamin C on bleeding and pain after kidney biopsy: a randomized controlled trial.BMC medicine · 2026Trial
- The influence of high doses of vitamin C on functional recovery and postoperative pain in patients with trochanteric fracture after intramedullary nailing during a three-month follow-up: a full-scale study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Trial
- The effect of intravenous vitamin C administration on postoperative pain and intraoperative blood loss in older patients after intramedullary nailing of trochanteric fractures.European geriatric medicine · 2025Trial
- Effects of Multiple Intravenous Doses of Perioperative Vitamin C on Pain Management Following Total Hip Arthroplasty.Drug design, development and therapy · 2025Trial
- Trial
- Intravenous vitamin C for bleeding control in elective C-sections: a randomized clinical trial study.Annals of medicine and surgery (2012) · 2026Article
- Role of Micronutrients in Perioperative Care: A Systematic Review.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- The Influence of Vitamin C on Postoperative Pain in Patients with Trochanteric Femur Fracture.Anesthesiology and pain medicine · 2026Article
- Comprehensive Approaches to Pain Management in Postoperative Spinal Surgery Patients: Advanced Strategies and Future Directions.Neurology international · 2025Review
- Vitamin C as an Adjuvant Analgesic Therapy in Postoperative Pain Management.Journal of clinical medicine · 2025Review
- The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.The archives of bone and joint surgery · 2025Review
- The Use of High-Dose Intravenous L-Ascorbate in Pain Therapy: Current Evidence from the Literature.Pain and therapy · 2024Review
- Unveiling the potential impact of vitamin C in postoperative spinal pain.Chinese neurosurgical journal · 2024Review
- Article
- Article
- Vitamin C: From Bench to Bedside.Nutrients · 2021Article
- Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination.Nutrients · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because the analgesic effect of vitamin C against acute pain remains poorly addressed, this meta-analysis aimed at investigating its effectiveness against acute postoperative pain. A total of seven randomized controlled trials with placebo/normal controls were identified from PubMed, Cochrane Library, Medline, Google Scholar, and Embase databases. Pooled analysis showed a lower pain score (standardized mean difference (SMD) = -0.68, 95% CI: -1.01 to -0.36,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.