ReviewAnimals : an open access journal from MDPI2020
Relationship between Vitamin B12 and Cobalt Metabolism in Domestic Ruminant: An Update.
Review in Animals : an open access journal from MDPI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
60 citing papers in PubMed, 176 citations in OpenAlex.
- Effect of partial replacement of potassium sources combined with cobalt on wheat (Triticum aestivum L.) growth and yield parameters.Scientific reports · 2026Article
- Nutritional and Functional Fortification of Cultivated Meat: A Scoping Review.Foods (Basel, Switzerland) · 2026Review
- Rumen-derived Prevotella and Megasphaera elsdenii mitigate methane production through functional modulation of rumen microbial metabolism.Journal of animal science and biotechnology · 2026Article
- Gut microbiota and meat quality in ruminants: a review of mechanisms and microbiota-targeted interventions.Food science of animal resources · 2026Review
- Serum Macro- and Trace-Element Alterations and Redox Imbalance in Cattle with Naturally Occurring Dermatophytosis.Animals : an open access journal from MDPI · 2026Article
- Article
- Folate as a Key Regulator of Animal Intestinal Homeostasis: From Metabolism to Microbiota and Barrier Function.Animals : an open access journal from MDPI · 2026Review
- Multi-Country Study of Stable Isotopes and Mineral Elements in European Pork.Foods (Basel, Switzerland) · 2026Article
- Multi-Organ Approaches to Cultivated Meat Biomanufacturing: Conceptual Applications of Ruminal Fermentation and Co-Cultures.Journal of food science · 2026Review
- Immunostimulatory and Immunomodulatory Effects of Vitamin B12 Derivatives on Macrophages Through the Modulation of JNK Pathway.Cell biochemistry and biophysics · 2026Article
- The Role of Five Key Minerals (Cu, Se, Zn, Co, Fe) in Reproductive Function of Female Cattle: Current Insights and Future Directions.Veterinary sciences · 2026Review
- Metal Concentrations in Edible Leafy Vegetables and Their Potential Risk to Human Health.International journal of environmental research and public health · 2026Article
- Bioaccumulation of Heavy Metals (17 Elements) in the Liver and Kidneys of the Least Weasel (Toxics · 2026Article
- A comprehensive ruminant microbial catalog (CRMC) reveals convergent selection for key vitamin-synthesizing pathways and genes across ruminants and human.GigaScience · 2026Article
- Review: Shifts of rumen microbiota by feeding non-fibrous carbohydrates to improve cattle performance.Frontiers in microbiology · 2026Review
- Current Understanding of Bovine Ketosis: From Molecular Basis to Farm-Level Management.Animals : an open access journal from MDPI · 2025Review
- Effects of 5,6-dimethylbenzimidazole and cobalt supplementation in high-concentrate diets on rumen fermentation and microorganisms and ruminal metabolome in sheep.BMC veterinary research · 2025Article
- Cobalt and Vitamin B12 in Dairy Cattle Nutrition: Requirements, Functions, and Interactions.Animals : an open access journal from MDPI · 2025Review
- Nanozymes or Spirulina Platensis: Enhancing Sheep Thermo-Tolerance Through Physio-Metabolic, Immune, and Antioxidant Pathways.Biological trace element research · 2025Article
- Relationship between theAnimal biotechnology · 2025Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cobalt, as a trace element, is essential for rumen microorganisms for the formation of vitamin B12. In the metabolism of mammals, vitamin B12 is an essential part of two enzymatic systems involved in multiple metabolic reactions, such as in the metabolism of carbohydrates, lipids, some amino acids and DNA. Adenosylcobalamin and methylcobalamin are coenzymes of methylmalonyl coenzyme A (CoA) mutase and methionine synthetase and are essential for obtaining energy through ruminal metabolism. Signs of cobalt deficiency range from hyporexia, reduced growth and weight loss to liver steatosis, anemia, impaired immune function, impaired reproductive function and even death. Cobalt status in ruminant animals can be assessed by direct measurement of blood or tissue concentrations of cobalt or vitamin B12, as well as the level of methylmalonic acid, homocysteine or transcobalamin in blood; methylmalonic acid in urine; some variables hematological; food consumption or growth of animals. In general, it is assumed that the requirement for cobalt (Co) is expressed around 0.11 ppm (mg/kg) in the dry matter (DM) diet; current recommendations seem to advise increasing Co supplementation and placing it around 0.20 mg Co/kg DM. Although there is no unanimous criterion about milk production, fattening or reproductive rates in response to increased supplementation with Co, in some investigations, when the total Co of the diet was approximately 1 to 1.3 ppm (mg/kg), maximum responses were observed in the milk production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.