Evidence map›Paper›PMID 33053382›Full record

ArticleBehavioural brain research2021

The motivational valence of methamphetamine relates inversely to subsequent methamphetamine self-administration in female C57BL/6J mice.

Gabriella Shab, Elissa K Fultz, Ariana Page, Michal A Coelho, Lindsey W Brewin, Nicholas Stailey, Chelsea N Brown, Camron D Bryant, Tod E Kippin, Karen K Szumlinski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Gabriella ShabDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA.
Elissa K FultzDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA.
Ariana PageDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA.
Michal A CoelhoDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA.
Lindsey W BrewinDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA.
Nicholas StaileyDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA.
Chelsea N BrownDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA.
Camron D BryantDepartment of Pharmacology and Experimental Therapeutics and Psychiatry, Boston University School of Medicine, Boston, MA, USA.
Tod E KippinDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA; Department of Molecular, Cellular and Developmental Biology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA, USA; Institute for Collaborative Biology, University of California at Santa Barbara, Santa Barbara, CA, USA.
Karen K SzumlinskiDepartment of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA, USA; Department of Molecular, Cellular and Developmental Biology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA, USA. Electronic address: szumlinski@ucsb.edu.
University of California, Santa Barbara · USBoston University · US

Funding

Bridging genetic variation with behavior: Molecular and functional mechanisms of quantitative trait gene regulation of the stimulant and addictive properties of methamphetamine in miceR01DA039168 · NIDA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BRYANT, CAMRON D · 2015 to 2019
$3.0M
Interactions between prenatal stress and genetics in cocaine responsiveness.R01DA027525 · NIDA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI KIPPIN, TOD EDWARD · 2010 to 2014
$1.6M
Homer-mediated signaling and cocaine addictionR01DA024038 · NIDA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SZUMLINSKI, KAREN KATHLEEN · 2008 to 2012
$1.5M
NIDA NIH HHS R01 DA024038NIDA NIH HHS R01 DA027525NIDA NIH HHS R01 DA039168
6 · The paper itself

Abstract

Understanding the mechanisms underpinning individual variance in addiction vulnerability requires the development of validated, high-throughput screens. In a prior study of a large sample of male isogenic C57BL/6J mice, the direction and magnitude of methamphetamine (MA)-induced place-conditioning predicts the propensity to acquire oral MA self-administration, as well as the efficacy of MA to serve as a reinforcer. The present study examined whether or not such a predictive relationship also exists in females. Adult C57BL/6J females underwent a 4-day MA place-conditioning paradigm (once daily injections of 2 mg/kg) and were then trained to nose-poke for delivery of a 20 mg/L MA solution under increasing schedules of reinforcement, followed by dose-response testing (5-400 mg/L MA). Akin to males, 53 % of the females exhibited a conditioned place-preference, while 32 % of the mice were MA-neutral and 15 % exhibited a conditioned place-aversion. However, unlike males, the place-conditioning phenotype did not transfer to MA-reinforced nose-poking behavior under operant-conditioning procedures, with 400 mg/L MA intake being inversely correlated place-conditioning. While only one MA-conditioning dose has been assayed to date, these data indicate that sex does not significantly shift the proportion of C57BL/6J mice that perceive MA's interoceptive effects as positive, neutral or aversive. However, a sex difference appears to exist regarding the predictive relationship between the motivational valence of MA and subsequent drug-taking behavior; females exhibit MA-taking behavior and reinforcement, despite their initial perception of the stimulant interoceptive effects as positive, neutral or negative.

Indexed as

Amphetamine-Related DisordersAnimalsBehavior, AnimalCentral Nervous System StimulantsConditioning, ClassicalConditioning, OperantDisease Models, AnimalFemaleMethamphetamineMiceMice, Inbred C57BLMotivationSex CharacteristicsCentral Nervous System StimulantsMethamphetamineAddiction vulnerabilityConditioned place-preferenceMethamphetamineResiliencySelf-administrationSex differences

Identifiers

PMID33053382
PMCPMC7722188
OpenAlexW3092119889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.