ArticleJournal of the American Chemical Society2020
Deep Interrogation of Metabolism Using a Pathway-Targeted Click-Chemistry Approach.
Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Metabolic Labeling and Visualization of Isoprenoids Using Alkyne-Modified DMAPP Analogs in Bacillus subtilis.Angewandte Chemie (International ed. in English) · 2026Article
- Tracker Nanocatalyst for Screening of Intracellular Copper-Catalyzed Azide-Alkyne Cycloadditions.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Comparative Metabolomics Identifies the Roles of Acyl-CoA Oxidases in the Biosynthesis of Ascarosides and a Complex Family of SecretedACS chemical biology · 2025Article
- Bio-orthogonal Glycan Imaging of Cultured Cells and Whole AnimalACS central science · 2025Article
- An acyl-CoA thioesterase is essential for the biosynthesis of a key dauer pheromone in C. elegans.Cell chemical biology · 2024Article
- Amino acid and protein specificity of protein fatty acylation inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Click chemistry-based enrichment strategy for tracing cellular fatty acid metabolism by LC-MS/MS.Journal of pharmaceutical analysis · 2023Article
- Repurposing degradation pathways for modular metabolite biosynthesis in nematodes.Nature chemical biology · 2023Review
- Small molecule metabolites: discovery of biomarkers and therapeutic targets.Signal transduction and targeted therapy · 2023Review
- Sex-specificity of the C. elegans metabolome.Nature communications · 2023Article
- Article
- Endocrine pheromones couple fat rationing to dauer diapause through HNF4α nuclear receptors.Science China. Life sciences · 2021Article
- Combinatorial Assembly of Modular Glucosides via Carboxylesterases RegulatesJournal of the American Chemical Society · 2021Article
- Nematode Signaling Molecules Are Extensively Metabolized by Animals, Plants, and Microorganisms.ACS chemical biology · 2021Article
- Deciphering the mechanism of action of antitubercular compounds with metabolomics.Computational and structural biotechnology journal · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Untargeted metabolomics indicates that the number of unidentified small-molecule metabolites may exceed the number of protein-coding genes for many organisms, including humans, by orders of magnitude. Uncovering the underlying metabolic networks is essential for elucidating the physiological and ecological significance of these biogenic small molecules. Here we develop a click-chemistry-based enrichment strategy, DIMEN (deep interrogation of metabolism via enrichment), that we apply to investigate metabolism of the ascarosides, a family of signaling molecules in the model organism
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Registered trials
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