ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2021
Multimorbidity in asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Allergy burden score and lung function impairment in children with asthma: a dose-response cross-sectional study.European journal of pediatrics · 2026Article
- Pulmonary microbiota-associated formononetin modulates microglial activation in asthma-related anxiety.Journal of neuroinflammation · 2026Article
- Association between allergic diseases and mucosal healing in ulcerative colitis.Scientific reports · 2025Article
- Monosensitization vs Polysensitization in Severe Asthma: Implications for Disease Severity.Journal of asthma and allergy · 2025Article
- Allergy in Young Adults Associates with Elevated Fractional Exhaled Nitric Oxide Levels and IgE-Verified Parental Allergy but Is Confounded by Self-Reported Symptoms.International archives of allergy and immunology · 2024Article
- Associations of Multimorbidity with Cerebrospinal Fluid Biomarkers for Neurodegenerative Disorders in Early Parkinson's Disease: A Crosssectional and Longitudinal Study.Current Alzheimer research · 2024Article
- Allergic rhinitis and other comorbidities associated with asthma control in Thailand.Frontiers in medicine · 2023Article
- Novel multimorbidity clusters in people with eczema and asthma: a population-based cluster analysis.Scientific reports · 2022Article
- Allergic multimorbidity is associated with self-reported anaphylaxis in adults-A cross-sectional questionnaire study.Clinical and translational allergy · 2022Article
- Anxiety-like behavior and intestinal microbiota changes as strain-and sex-dependent sequelae of mild food allergy in mouse models of cow's milk allergy.Brain, behavior, and immunity · 2021Article
- Multimorbidity in asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GAClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Association Between a Type 2 Inflammatory Disease Burden Score and Outcomes Among Patients with Asthma.Journal of asthma and allergy · 2021Article
- [Unmet Needs in Severe Allergic Asthma].Open respiratory archivesArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma is common worldwide and a large part of subjects with asthma have concomitant allergic multimorbidity in the form of rhinitis and/or eczema.
objectiveThe aim of this study is to investigate whether the presence of allergic multimorbidity in asthma relates to allergic sensitization, allergic and respiratory symptoms, quality of life, inflammatory markers, lung function, use of medication and background factors.
methodsA total of 437 asthmatics from the (GA
resultsSubjects with asthma, rhinitis and eczema were more likely to be sensitized to seasonal allergens (67% vs 32%, P < .001), food allergens (54% vs 18%, P < .001) and to have a higher degree of sensitization than subjects with only asthma (23% vs 10%, P < .001). Subjects with allergic multimorbidity more often had allergic reactions to food (28% vs 10%, P = .002), more respiratory symptoms and anxiety/depression (40% vs, 14%, P < .001) than subjects with only asthma, despite having similar levels of type 2 inflammatory markers. Individuals with allergic multimorbidity were more likely to be diagnosed with asthma before the age of 12 (48% vs 27%, P = .016) and to have maternal heredity for allergy (53% vs 33%, P = .011) than subjects with only asthma. CONCLUSION AND CLINICAL RELEVANCE: Asthmatics with allergic multimorbidity are more likely to be sensitized to seasonal aeroallergens, food allergens and they have a higher degree of sensitization compared with those with only asthma. Allergic multimorbidity is associated with respiratory and allergy symptoms, anxiety and/or depression.
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