Evidence map›Paper›PMID 33053230›Full record

ArticleJournal of cellular biochemistry2021

SCF FBXW17 E3 ubiquitin ligase regulates FBXL19 stability and cell migration.

Su Dong, Jianxin Wei, Rachel K Bowser, Bill B Chen, Rama K Mallampalli, Jiaxing Miao, Qinmao Ye, Kevin C Tran, Yutong Zhao, Jing Zhao

Open access · greenAbstract read
In one paragraph

Article in Journal of cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. SKP1-CUL1-F-box: Key molecular targets affecting disease progression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Su DongDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Jianxin WeiDepartment of Medicine, The University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rachel K BowserDepartment of Medicine, The University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Bill B ChenDepartment of Medicine, The University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rama K MallampalliPulmonary, Critical Care, and Sleep Medicine Division, The Ohio State University, Columbus, Ohio, USA.
Jiaxing MiaoDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Qinmao YeDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Kevin C TranDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Yutong ZhaoDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Jing ZhaoDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-0211-9289
The Ohio State University · USUniversity of Pittsburgh · US

Funding

Systematic Investigation of Protein Ubiquitination in ARDSR35HL139860 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, BEIBEI · 2018 to 2024
$6.3M
F box-Induced Acute Lung Injury and ParkinR01HL096376 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2010 to 2025
$5.1M
Molecular regulation of anti-inflammatory cytokine receptor in sepsisR01HL136294 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHAO, YUTONG · 2018 to 2021
$1.8M
Deubiquitinating and inhibiting Hsp90 by USP40 mitigates lung injuryR01HL151513 · NHLBI · OHIO STATE UNIVERSITY · PI ZHAO, JING · 2020 to 2023
$1.7M
Regulation of proteolysis by deubiquiting enzyme in lung inflammatory diseaseR01HL131665 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHAO, YUTONG · 2017 to 2020
$1.5M
Regulation of Histone Acetyltransferase Stability In SepsisR01GM115389 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHAO, JING · 2015 to 2019
$1.5M
Regulation of the IL-33 receptor, ST2L, by Protein Stability in Septic InjuryR01HL112791 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHAO, YUTONG · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL096376NHLBI NIH HHS R01 HL112791NHLBI NIH HHS R01 HL131665NHLBI NIH HHS R01 HL136294NHLBI NIH HHS R01 HL151513NHLBI NIH HHS R35 HL139860NIGMS NIH HHS R01 GM115389
6 · The paper itself

Abstract

The Skp1-Cul1-F-box protein (SCF) E3 ligase complex is one of the largest ubiquitin E3 ligase families. FBXL19, a F-box protein in SCF

Indexed as

AcetylationAnimalsCell LineCell MovementDNA-Binding ProteinsF-Box ProteinsImmunoblottingImmunoprecipitationMicerac1 GTP-Binding ProteinRNA, Small InterferingUbiquitinationDNA-Binding ProteinsF-Box ProteinsFBXL19 protein, mouserac1 GTP-Binding ProteinRNA, Small Interferingcell migrationF-box proteinprotein degradationSCF E3 ligaseubiquitination

Identifiers

PMID33053230
PMCPMC7887023
OpenAlexW3093218912

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.