ArticlePLoS neglected tropical diseases2020
Tripartite interactions: Leishmania, microbiota and Lutzomyia longipalpis.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Baseline Characterization of the Gut Microbiota of Field and Colony Populations ofPathogens (Basel, Switzerland) · 2026Article
- Report of the Seventh Post-Kala-Azar Dermal Leishmaniasis Consortium meeting, Kolkata, India, 28-29 November 2024.Parasites & vectors · 2026Article
- The genome of Phlebotomus chinensis, the primary vector of visceral leishmaniasis in China: insights from chromosome-level assembly and comparative analysis.Infectious diseases of poverty · 2026Article
- Structure and Diversity of the Microbiome in Amazonian Sand Flies: Insights into Vector-Microbe Interactions.Microbial ecology · 2026Article
- C14DM Ablation Leads to Reduced Tolerance to Plasma Membrane Stress and Increased Drug Sensitivity inInternational journal of molecular sciences · 2025Article
- Investigation of bacterial microbiota variability in two allopatric populations of Nyssomyia umbratilis, susceptible and nonsusceptible to Leishmania (Viannia) guyanensis infection in the Amazon region.Parasites & vectors · 2025Article
- Metagenomic Analyses of Gut Bacteria of Two Sandfly Species from Western Ghats, India, Differing in Their Vector Competence for Leishmaniasis.Microorganisms · 2025Article
- Leishmania sand fly-transmission is disrupted by Delftia tsuruhatensis TC1 bacteria.Nature communications · 2025Article
- From pre-oral secretions to gut digestion: How do Lucilia sericata (Diptera: Calliphoridae) larvae handle Leishmania major?PloS one · 2025Article
- Humidity and temperature preference in two Neotropical species of sand flies.Parasites & vectors · 2024Article
- Immune Reactions of Vector Insects to Parasites and Pathogens.Microorganisms · 2024Review
- Effects of Leishmania major infection on the gut microbiome of resistant and susceptible mice.Applied microbiology and biotechnology · 2024Article
- Interactions between Leishmania parasite and sandfly: a review.Parasitology research · 2023Review
- Microbiota in disease-transmitting vectors.Nature reviews. Microbiology · 2023Review
- Effects of host species on microbiota composition in Phlebotomus and Lutzomyia sand flies.Parasites & vectors · 2023Article
- Beyond canonical models: why a broader understanding of Diptera-microbiota interactions is essential for vector-borne disease control.Evolutionary ecology · 2023Article
- Co-infection ofFrontiers in cellular and infection microbiology · 2023Article
- Host-Parasite Interactions: Regulation of Leishmania Infection in Sand Fly.Acta parasitologica · 2022Review
- The influence of culture-dependent native microbiota in Zika virus infection in Aedes aegypti.Parasites & vectors · 2022Article
- Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The microbial consortium associated with sandflies has gained relevance, with its composition shifting throughout distinct developmental stages, being strongly influenced by the surroundings and food sources. The bacterial components of the microbiota can interfere with Leishmania development inside the sandfly vector. Microbiota diversity and host-microbiota-pathogen interactions regarding New World sandfly species have yet to be thoroughly studied, particularly in Lutzomyia longipalpis, the primary vector of visceral leishmaniasis in Brazil.The native microbiota of different developmental stages and physiological conditions of Lu. longipalpis (Lapinha Cave), was described by culturing and 16s rRNA gene sequencing. The 16s rRNA sequencing of culture-dependent revealed 13 distinct bacterial genera (Bacillus, Enterococcus, Erwinia, Enterobacter, Escherichia, Klebsiella, Lysinibacillus, Pseudocitrobacter, Providencia, Pseudomonas, Serratia, Staphylococcus and Solibacillus). The in vitro and in vivo effects of each one of the 13 native bacteria from the Lu. longipalpis were analyzed by co-cultivation with promastigotes of L.i. chagasi, L. major, L. amazonensis, and L. braziliensis. After 24 h of co-cultivation, a growth reduction observed in all parasite species. When the parasites were co-cultivated with Lysinibacillus, all parasites of L. infantum chagasi and L. amazonensis died within 24 hours. In the in vivo co-infection of L.chagasi, L. major and L. amazonensis with the genera Lysinibacillus, Pseudocitrobacter and Serratia it was possible to observe a significant difference between the groups co-infected with the bacterial genera and the control group.These findings suggest that symbiont bacteria (Lysinibacillus, Serratia, and Pseudocitrobacter) are potential candidates for paratransgenic or biological control. Further studies are needed to identify the nature of the effector molecules involved in reducing the vector competence for Leishmania.
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