ArticlePLoS neglected tropical diseases2020
TSOL18 vaccine and oxfendazole for control of Taenia solium cysticercosis in pigs: A field trial in endemic areas of Tanzania.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Neurocysticercosis control for primary epilepsy prevention: a systematic review.Pathogens and global health · 2022Pooled it
- mRNA based vaccines and therapeutics for parasitic infections: a comprehensive review.Journal of nanobiotechnology · 2025Review
- Integrating neurological expertise into One Health strategies for pediatric neurocysticercosis-associated epilepsy control in Sub-Saharan Africa: a narrative review.One health outlook · 2025Review
- Structural insights into sigma class glutathione transferase from Taenia solium: Analysis and functional implications.PLoS neglected tropical diseases · 2025Article
- High prevalence of porcine cysticercosis in slaughtered pigs in Rwanda: An abattoir survey.PLoS neglected tropical diseases · 2024Article
- Prevalence ofFood and waterborne parasitology · 2024Article
- Insights into the diagnosis, vaccines, and control of Taenia solium, a zoonotic, neglected parasite.Parasites & vectors · 2023Review
- Aggregation ofParasite epidemiology and control · 2023Review
- Article
- Changing food systems and infectious disease risks in low-income and middle-income countries.The Lancet. Planetary health · 2022Review
- Parasitology and One Health-Perspectives on Africa and Beyond.Pathogens (Basel, Switzerland) · 2021Article
- Control trial of porcine cysticercosis in Uganda using a combination of the TSOL18 vaccination and oxfendazole.Infectious diseases of poverty · 2021Article
- Maximising Societal Benefit From the Control of Neglected Zoonoses: Identifying Synergies and Trade-Offs in the Control ofFrontiers in veterinary science · 2021Review
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A field trial was conducted in Tanzania to determine the effectiveness of TSOL18 vaccine used concurrently with oxfendazole (OFZ), and of OFZ alone, on T. solium cysticercosis determined by organ and half carcase dissection of slaughter age pigs. This study followed a quasi-experimental group design. Suitable trial sites were randomly allocated to either treatment group T1 (OFZ treatment alone [30mg/kg, Paranthic 10%]) or T2 (TSOL18 [1ml, Cysvax] plus OFZ). Three 4-monthly treatments were administered to eligible pigs. A random selection of pigs were necropsied at baseline and at endline, 2-3.5 months after the final treatment. Additionally, untreated pigs from T1 and T2 areas were necropsied at endline to provide contemporaneous comparisons with T1 and T2 pigs. Baseline prevalence of viable T. solium cysticerci for T1 was 25.5% (Exact 95% CI: 13.9, 40.3; n = 12/47), and for T2 was 12.0% (CI: 6.4, 20.0; n = 12/100). At endline, prevalence was 2.8% for T1 (CI: 0.1, 14.5, n = 1/36) and 0% for T2 (CI: 0, 4.7, n = 0/77). Among untreated pigs, three had viable cysticerci, one from T1 area (12.5%, CI: 0.3, 52.7; n = 1/8) and two from T2 area (5.7%, CI: 0.7, 19.2, n = 2/35). Fisher's exact test showed significant changes in prevalence from baseline to endline in both groups (T1: p = 0.005, T2: p = 0.001). Firth's penalized Maximum Likelihood method suggested the changes were not significant relative to their controls (T1: p = 0.245, T2: p = 0.076). These findings showed a significant reduction in the prevalence of viable cysticerci from baseline to endline after both interventions. However, the changes could not be definitively attributed to the interventions due, in part, to small numbers of control pigs. Concurrent administration of the TSOL18 and OFZ cleared infection among assessed pigs whereas infection remained after treatment with OFZ only. Further studies including larger sample sizes would be required for more definitive conclusions. A One Health approach is recommended for rapid and sustainable impact.
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