Evidence map›Paper›PMID 33052900›Full record

ArticlePLoS biology2020

A functional context for heterogeneity of the circadian clock in cells.

Martha Merrow, Mary Harrington

Abstract readComment
In one paragraph

Article in PLoS biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Martha MerrowInstitute of Medical Psychology, Medical Faculty, LMU Munich, Munich, Germany.ORCID 0000-0002-8688-2360
Mary HarringtonNeuroscience Program, Smith College, Northampton, Massachusetts, United States of America.ORCID 0000-0003-2266-6455

Funding

In vivo tracking of bioluminescent markers of circadian rhythms in behaving animalsR15GM126545 · NIGMS · SMITH COLLEGE · PI HARRINGTON, MARY E · 2017 to 2024
$1.2M
NIGMS NIH HHS R15 GM126545
6 · The paper itself

Abstract

Characterization of circadian systems at the organism level-a top-down approach-has led to definition of unifying properties, a hallmark of the science of chronobiology. The next challenge is to use a bottom-up approach to show how the molecular workings of the cellular circadian clock work as building blocks of those properties. We review new studies, including a recently published PLOS Biology paper by Nikhil and colleagues, that show how programmed but also stochastic generation of variation in cellular circadian period explain important adaptive features of entrained circadian phase.

Indexed as

Circadian ClocksCell Physiological Phenomena

Identifiers

PMID33052900
PMCPMC7671520

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.