ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2021
Phase-Aberration Correction for HIFU Therapy Using a Multielement Array and Backscattering of Nonlinear Pulses.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biological current source imaging method based on acoustoelectric effect: A systematic review.Frontiers in neuroscience · 2022Pooled it
- Ultrasound Imaging: A Cornerstone of the Entire High-Intensity Focused Ultrasound Tumor Treatment Continuum.Diagnostics (Basel, Switzerland) · 2026Review
- High-intensity focused ultrasound (HIFU) modeling: in vitro validation and integration into patient-specific planning tool.Scientific reports · 2026Article
- Three-dimensional passive acoustic mapping of high intensity focused ultrasound fields using sparse synthetic apertures from rotated one-dimensional linear arrays.Scientific reports · 2026Article
- Aberration correction expands the treatment envelope for histotripsy in the liver.Physics in medicine and biology · 2025Article
- A Fully Populated Transrectal Array for Boiling Histotripsy Ablation of the Prostate.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Neuronavigation-Guided Transcranial Acoustoelectric Brain Imaging: A New Modality for High Resolution Electrical Brain Mapping.IEEE transactions on bio-medical engineering · 2025Article
- Synthesized acoustic holography: A method to evaluate steering and focusing performance of ultrasound arrays.The Journal of the Acoustical Society of America · 2025Article
- In Vivo Cavitation-Based Aberration Correction of Histotripsy in Porcine Liver.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Acoustoelectric Time-Reversal for Ultrasound Phase-Aberration Correction.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Soft Tissue Aberration Correction for Histotripsy Using Acoustic Emissions From Cavitation Cloud Nucleation and Collapse.Ultrasound in medicine & biology · 2023Article
- The histotripsy spectrum: differences and similarities in techniques and instrumentation.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023Review
- Aberration correction in abdominal histotripsy.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023Review
- A Modular, Kerf-Minimizing Approach for Therapeutic Ultrasound Phased Array Construction.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- In Vivo Aberration Correction for Transcutaneous HIFU Therapy Using a Multielement Array.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Effects of phase aberration on transabdominal focusing for a large aperture, lowPhysics in medicine and biology · 2022Article
- Robust and durable aberrative and absorptive phantom for therapeutic ultrasound applications.The Journal of the Acoustical Society of America · 2022Article
- Ultrastructural Analysis of Volumetric Histotripsy Bio-effects in Large Human Hematomas.Ultrasound in medicine & biology · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Phase aberrations induced by heterogeneities in body wall tissues introduce a shift and broadening of the high-intensity focused ultrasound (HIFU) focus, associated with decreased focal intensity. This effect is particularly detrimental for HIFU therapies that rely on shock front formation at the focus, such as boiling histotripsy (BH). In this article, an aberration correction method based on the backscattering of nonlinear ultrasound pulses from the focus is proposed and evaluated in tissue-mimicking phantoms. A custom BH system comprising a 1.5-MHz 256-element array connected to a Verasonics V1 engine was used as a pulse/echo probe. Pulse inversion imaging was implemented to visualize the second harmonic of the backscattered signal from the focus inside a phantom when propagating through an aberrating layer. Phase correction for each array element was derived from an aberration-correction method for ultrasound imaging that combines both the beamsum and the nearest neighbor correlation method and adapted it to the unique configuration of the array. The results were confirmed by replacing the target tissue with a fiber-optic hydrophone. Comparing the shock amplitude before and after phase-aberration correction showed that the majority of losses due to tissue heterogeneity were compensated, enabling fully developed shocks to be generated while focusing through aberrating layers. The feasibility of using a HIFU phased-array transducer as a pulse-echo probe in harmonic imaging mode to correct for phase aberrations was demonstrated.
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