ReviewPhysiology (Bethesda, Md.)2020
Phenotypic Frailty Assessment in Mice: Development, Discoveries, and Experimental Considerations.
Review in Physiology (Bethesda, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Elevating Circulating L-Kynurenine Promotes Frailty in Aging Mice.Journal of cachexia, sarcopenia and muscle · 2026Article
- Frailty increases vulnerability to postoperative cognitive dysfunction following general anesthesia in aged rats.International journal of medical sciences · 2026Article
- Frailty Assessment in an Aging Mouse Model.Journal of visualized experiments : JoVE · 2025Article
- Evaluating frailty assessment tools and biological frailty markers in C57BL/6 female mice.GeroScience · 2025Article
- The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise.FEBS open bio · 2025Article
- Overlapping and Distinct Physical and Biological Phenotypes in Pure Frailty and Obese Frailty.Bioscience reports · 2024Article
- Ergothioneine promotes longevity and healthy aging in male mice.GeroScience · 2024Article
- Stem cell secretome treatment improves whole-body metabolism, reduces adiposity, and promotes skeletal muscle function in aged mice.Aging cell · 2024Article
- Unveiling frailty: comprehensive and sex-specific characterization in prematurely aging PolgA mice.Frontiers in aging · 2024Article
- Adaptability to eccentric exercise training is diminished with age in female mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Comprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatric C57BL/6 J mice.GeroScience · 2023Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Age of Peak Performance Differs by Functional Task in Mice Tracked Over 2 Years.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Shifts in Gait Signatures Mark the End of Lifespan in Mice, With Sex Differences in Timing.Frontiers in aging neuroscience · 2021Article
- Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models?Advances in geriatric medicine and research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The underlying mechanisms contributing to the onset of frailty, its progression, and its mortality risk remain unknown. Recently, the two most common human frailty assessments were reverse-translated to mice. Here, we highlight the development of the mouse frailty phenotype, unique discoveries, experimental considerations, and future perspectives.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.