Evidence map›Paper›PMID 33052764›Full record

ReviewAnnual review of medicine2021

Microbiota Effects on Carcinogenesis: Initiation, Promotion, and Progression.

Lacey R Lopez, Rachel M Bleich, Janelle C Arthur

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Translational cancer research · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Modulating the microbiome as an approach to anticancer drug development.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Lacey R LopezDepartment of Microbiology and Immunology, The University of North Carolina, Chapel Hill, North Carolina 27599, USA; email: laceylop@email.unc.edu, janelle_arthur@med.unc.edu.
Rachel M BleichDepartment of Biology, Appalachian State University, Boone, North Carolina 28608, USA; email: bleichrm@appstate.edu.
Janelle C ArthurDepartment of Microbiology and Immunology, The University of North Carolina, Chapel Hill, North Carolina 27599, USA; email: laceylop@email.unc.edu, janelle_arthur@med.unc.edu.
University of North Carolina at Chapel Hill · USAppalachian State University · US

Funding

SEEDING POSTDOCTORAL INNOVATORS IN RESEARCH &EDUCATIONK12GM000678 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DONALD T LYSLE, Kathryn Joanna Reissner · 1999 to 2026
$30.9M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
Microbiota-mediated fibrotic remodeling in the inflamed intestineR01DK124617 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARTHUR, JANELLE C · 2020 to 2024
$1.9M
NIDDK NIH HHS P30 DK034987NIDDK NIH HHS R01 DK124617NIGMS NIH HHS K12 GM000678
6 · The paper itself

Abstract

Carcinogenesis is a multistep process by which normal cells acquire genetic and epigenetic changes that result in cancer. In combination with host genetic susceptibility and environmental exposures, a prominent procarcinogenic role for the microbiota has recently emerged. In colorectal cancer (CRC), three nefarious microbes have been consistently linked to cancer development: (

Indexed as

MicrobiotaCarcinogenesisCell Transformation, NeoplasticColorectal NeoplasmsDisease ProgressionHumansB. fragilis toxincarcinogenesiscolibactincolorectal cancerFusobacteriummicrobiota

Identifiers

PMID33052764
PMCPMC10202020
OpenAlexW3092977321

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.