Evidence map›Paper›PMID 33052620›Full record

ArticleExperimental physiology2020

Activation of the 5-HT

Bridget M Seitz, Gregory D Fink, Stephanie W Watts

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. 5-Hydroxytryptamine may be a viable treatment option for hypertension resistant to diuretic treatment.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  2. Review
  3. 5-HTMicrocirculation (New York, N.Y. : 1994) · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Bridget M SeitzDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.
Gregory D FinkDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.
Stephanie W WattsDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-9653-6357
Michigan State University · US

Funding

5-HT7 receptor and blood pressure regulationR01HL151413 · NHLBI · MICHIGAN STATE UNIVERSITY · PI FINK, GREGORY D, WATTS, STEPHANIE W · 2020 to 2023
$1.7M
NHLBI NIH HHS R01 HL151413
6 · The paper itself

Abstract

NEW

findingsWhat is the central question of this study? What mechanisms account for the hypotension observed during chronic elevations in circulating 5-hydroxytryptamine in rats? What is the main finding and its importance? Chronic 5-hydroxytryptamine-induced hypotension requires continued activation of the 5-HT ABSTRACT: Low dose infusion of 5-hydroxytryptamine (5-HT) to rats causes both an acute and a chronic fall in arterial blood pressure. The 5-HT

Indexed as

AnimalsArginineArterial PressureBlood PressureEnzyme InhibitorsHeart RateHypotensionMaleNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseRatsRats, Sprague-DawleyReceptors, SerotoninSerotoninVasoconstrictor AgentsArgininearginine methyl esterEnzyme InhibitorsNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseReceptors, SerotoninSerotoninserotonin 7 receptorVasoconstrictor Agents5-HT5-HT7 receptorhypotensionnitric oxide synthase

Identifiers

PMID33052620
PMCPMC7902303
OpenAlexW3092239850

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.