SynthesisSurgical endoscopy2021
Endoscopic ultrasound-guided parenchymal liver biopsy: a systematic review and meta-analysis.
Synthesis in Surgical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05817994 (Registry of Endoscopic Ultrasound Guided Assessment of the Liver), which is not on this map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Registry of Endoscopic Ultrasound Guided Assessment of the Liver (REGAL Study)
Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Endoscopic ultrasound-guided intraportal injection of autologous bone marrow in patients with decompensated liver cirrhosis: A case series.World journal of gastrointestinal surgery · 2023Trial
- Development and validation of 3D-printed anatomically accurate liver model for endoscopic ultrasound-based endo-hepatology training (with video).Surgical endoscopy · 2026Article
- Needle Types and Diagnostic Accuracy in EUS-Guided Liver Biopsy: A Systematic Review and Network Meta-Analysis.Diagnostics (Basel, Switzerland) · 2026Review
- Technical considerations in endoscopic ultrasound-guided liver biopsy: A comprehensive review.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Review
- Comparative diagnostic efficacy and safety of ultrasound-guided percutaneous transhepatic biopsy and endoscopic ultrasound-guided fine-needle aspiration biopsy for gallbladder tumors.Scientific reports · 2025Article
- Endo-hepatology: Why should we do endoscopic ultrasound-guided interventions to the liver that we could do through the skin?World journal of gastroenterology · 2024Article
- [Endoscopic ultrasound-guided liver biopsy: current status and prospects].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024Review
- Clinical value of [Japanese journal of radiology · 2024Article
- Current perspectives on the diversification of endoscopic ultrasound-guided fine-needle aspiration and biopsy.Journal of medical ultrasonics (2001) · 2024Review
- Comparison of diagnostic outcomes, safety, and cost of Franseen-tip 19G versus 22G needles for endoscopic ultrasound-guided liver biopsies.Endoscopy international open · 2024Article
- Role of endoscopic ultrasound and endoscopic ultrasound-guided tissue acquisition in diagnosing hepatic focal lesions.World journal of methodology · 2023Article
- Diagnostic efficacy of endoscopic ultrasound-guided liver biopsy for diffuse liver diseases and its predictors - a multicentric retrospective analysis.Clinical and experimental hepatology · 2023Article
- The Role of Endohepatology in the Management of Liver Disease.Gastroenterology & hepatology · 2023Article
- Article
- Advances in Endoscopic Ultrasound (EUS)-Guided Liver Biopsy.Diagnostics (Basel, Switzerland) · 2023Review
- Endoscopic Ultrasound-Guided Fine-Needle Biopsy versus Fine-Needle Aspiration in the Diagnosis of Focal Liver Lesions: Prospective Head-to-Head Comparison.Diagnostics (Basel, Switzerland) · 2022Article
- Update on endoscopic ultrasound-guided liver biopsy.World journal of gastroenterology · 2022Review
- Endoscopic ultrasound-guided liver biopsy: needle types and suction methods.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2021Article
- Role of Endoscopic Ultrasound in Liver Disease: Where Do We Stand?Diagnostics (Basel, Switzerland) · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic ultrasonography (EUS)-guided liver biopsy is a novel technique to obtain adequate liver samples for diagnosis of liver parenchymal diseases. There are studies that have evaluated the feasibility and safety of EUS-guided parenchymal liver biopsy (EUS-LB), however, factors that can influence specimen quality are yet to be determined. Our aim was to determine the diagnostic accuracy of EUS-LB and evaluate factors associated with specimen quality.
methodsWe performed a detailed search of PubMed/MEDLINE and Web of Science™ databases to identify studies in which results of EUS-guided liver parenchymal biopsies were reported published up to July 2020. A random effects model was used to estimate pooled values (mean ± SE) for total specimen length (TSL) and complete portal tracts (CPT). Subgroup analyses were applied to find out the procedural factors associated with better specimen quality using Cochran's Q test. A total of 10 meta-analyses were done focusing on international studies. Total of 1326 patients who underwent EUS-LB. EUS-LBs performed for suspicion of parenchymal liver disease. Pooled mean values for TSL and CPT with subgroup analyses.
resultsTwenty-three studies with a total of 1326 patients were included in our meta-analysis. Overall pooled mean TSL and CPT were 45.3 ± 4.6 mm and 15.8 ± 1.5, respectively. In subgroup analysis, core biopsy needles proved to better in terms of CPT than fine-needle aspiration needles (18.4 vs 10.99, p = 0.003). FNB with slow-pull or suction technique provided a similar TSL (44.3 vs 53.9 mm, p = 0.40), however, slow-pull technique was better in terms of CPT (30 vs 14.6, p < 0.001). Heterogeneity was present among the studies. Another limitation is the low number randomized control trials.
conclusionEUS-guided parenchymal liver biopsy is a good alternative to other methods of liver sampling. Using FNB needles with a slow-pull technique can provide better results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.