Evidence map›Paper›PMID 33052489›Full record

ArticleSurgery today2021

Predictive value of tumor-infiltrating lymphocytes for pathological response to neoadjuvant chemotherapy in breast cancer patients with axillary lymph node metastasis.

Tomoyo Yokotani, Noaya Ikeda, Tomoko Hirao, Yukimi Tanaka, Kohei Morita, Tomomi Fujii, Chiho Ohbayashi, Takashi Nakamura, Toyoki Kobayashi, Masayuki Sho

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Article in Surgery today, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Tomoyo YokotaniDepartment of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Noaya IkedaDepartment of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan. n-ikeda@naramed-u.ac.jp.
Tomoko HiraoDepartment of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Yukimi TanakaDepartment of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Kohei MoritaDepartment of Diagnostic Pathology, Nara Medical University, Nara, Japan.
Tomomi FujiiDepartment of Diagnostic Pathology, Nara Medical University, Nara, Japan.
Chiho OhbayashiDepartment of Diagnostic Pathology, Nara Medical University, Nara, Japan.
Takashi NakamuraDepartment of Breast Surgery, Nabari City Hospital, Mie, Japan.
Toyoki KobayashiDepartment of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Masayuki ShoDepartment of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Nara Medical University · JPNara City Hospital · JP

Funding

Japan Society for the Promotion of Science 18K08548
6 · The paper itself

Abstract

purposeWe investigated the role of tumor-infiltrating lymphocytes (TILs) in pretreatment primary breast cancer to predict pathological response to neoadjuvant chemotherapy (NAC) in patients with clinical node-positive disease (cN +).

methodsThe subjects of this study were 60 patients with cN + , who received NAC followed by breast surgery with axillary lymph node dissection (ALND). We conducted a semi-quantitative assessment of TILs in pretreatment primary tumors and their association with clinicopathological factors and axillary lymph node metastasis.

resultsWe observed a higher number of TILs in tumors with negative hormone receptors, positive human epidermal growth factor receptor 2, or high Ki67. TILs were associated with a favorable response to NAC in primary tumors. The rate of axillary pathologic complete response (Ax-pCR) was significantly higher in patients with a high number of TILs than in patients with a low number of TILs (72.0% versus 17.1%, p < 0.001). In multivariable analysis, a high number of TILs was a significant predictor of Ax-pCR as well as of pCR of the primary tumor after NAC. Importantly, all patients with HER2-positive tumors in the high TILs group showed Ax-pCR on ALND.

conclusionTILs in pretreatment primary breast cancer had the potential to predict therapeutic efficacy of NAC in patients with clinical node-positive disease.

Indexed as

Neoadjuvant TherapyAxillaBreast NeoplasmsErb-b2 Receptor Tyrosine KinasesFemaleForecastingHumansKi-67 AntigenLymphatic MetastasisLymph NodesLymphocytes, Tumor-InfiltratingTreatment OutcomeERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesKi-67 AntigenMKI67 protein, humanAxillary dissectionAxillary pathological complete responseBreast cancerNeoadjuvant chemotherapyTumor-infiltrating lymphocytes

Identifiers

PMID33052489
OpenAlexW3092071447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.