Evidence map›Paper›PMID 33052470›Full record

ArticleJournal of neurology2021

Autoimmune cortical encephalitis in two children with anti-myelin oligodendrocyte glycoprotein (MOG) antibody.

D Doig, C McNamara, L Mewasingh, S Beri, B Jones, C Kachramanoglou, W Jan

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Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

D DoigDepartment of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, WC1N 3BG, UK. david.doig@nhs.net.ORCID http://orcid.org/0000-0002-7492-6610
C McNamaraImaging Department, Imperial College Healthcare NHS Trust, London, UK.ORCID http://orcid.org/0000-0001-8164-7794
L MewasinghPaediatric Neurology Department, Imperial College Healthcare NHS Trust, London, UK.ORCID http://orcid.org/0000-0002-0340-302X
S BeriPaediatric Neurology Department, Imperial College Healthcare NHS Trust, London, UK.
B JonesImaging Department, Imperial College Healthcare NHS Trust, London, UK.ORCID http://orcid.org/0000-0002-6101-0283
C KachramanoglouImaging Department, Imperial College Healthcare NHS Trust, London, UK.ORCID http://orcid.org/0000-0002-7874-0944
W JanImaging Department, Imperial College Healthcare NHS Trust, London, UK.ORCID http://orcid.org/0000-0002-8803-7080
Imperial College Healthcare NHS Trust · GBUniversity College London Hospitals NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAnti-myelin oligodendrocyte glycoprotein antibodies (anti-MOG), directed against a component of the myelin sheath, are sometimes detected in the blood or cerebrospinal fluid (CSF) of patients with acute demyelinating conditions. Cortical encephalitic presentations in anti-MOG-antibody-positive patients are recognized but rare, and few pediatric cases have been described.

methodsWe describe clinical, biochemical, and MRI findings in two children presenting with generalized seizures due to cortical encephalitis, and review potential underlying immunological processes.

resultsIn both patients, anti-MOG antibodies were detected. Both underwent MRI scans which demonstrated bilateral cortical swelling and T2/fluid-attenuated inversion recovery (FLAIR) hyperintensity with corresponding regions of reduced diffusion.

conclusionEarly detection of anti-MOG antibodies in patients with a similar presentation and imaging features would enable rapid institution of appropriate treatment, and potentially reduce the need for invasive diagnostic procedures such as brain biopsy.

Indexed as

EncephalitisHashimoto DiseaseAutoantibodiesChildHumansMagnetic Resonance ImagingMyelin-Oligodendrocyte GlycoproteinAutoantibodiesMyelin-Oligodendrocyte GlycoproteinAnti-myelin oligodendrocyte glycoproteinDemyelinating diseasesEncephalitisMagnetic resonance imagingPediatricsRadiology

Identifiers

PMID33052470
OpenAlexW3092104289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.