Evidence map›Paper›PMID 33052463›Full record

ArticleEuropean radiology2021

Evaluation of a convolutional neural network for ovarian tumor differentiation based on magnetic resonance imaging.

Robin Wang, Yeyu Cai, Iris K Lee, Rong Hu, Subhanik Purkayastha, Ian Pan, Thomas Yi, Thi My Linh Tran, Shaolei Lu, Tao Liu and 7 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Pooled it
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  6. Artificial Intelligence in Obstetric and Gynecological MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Robin Wang *Department of Radiology, the Second Xiangya Hospital, Central South University, Changsha, China.
Yeyu Cai *Department of Radiology, the Second Xiangya Hospital, Central South University, Changsha, China.
Iris K LeePerelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Rong HuSchool of Computer Science and Engineering, Central South University, Changsha, China.
Subhanik PurkayasthaDepartment of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA.
Ian PanWarren Alpert Medical School at Brown University, Providence, RI, USA.
Thomas YiWarren Alpert Medical School at Brown University, Providence, RI, USA.
Thi My Linh TranWarren Alpert Medical School at Brown University, Providence, RI, USA.
Shaolei LuDepartment of Pathology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA.
Tao LiuDepartment of Biostatistics, Center for Statistical Sciences, Brown University School of Public Health, Providence, RI, USA.
Ken ChangDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.
Raymond Y HuangDepartment of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
Paul J ZhangDepartment of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Zishu ZhangPerelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Enhua XiaoDepartment of Radiology, the Second Xiangya Hospital, Central South University, Changsha, China.
Jing WuDepartment of Radiology, the Second Xiangya Hospital, Central South University, Changsha, China. wujing622@csu.edu.cn.
Harrison X BaiDepartment of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA. Harrison_Bai@Brown.edu.ORCID http://orcid.org/0000-0002-9614-2163
Brown University · USCentral South University · CNUniversity of Pennsylvania · USBrigham and Women's Hospital · USHospital of the University of Pennsylvania · USMassachusetts General Hospital · US

Funding

Neuroimaging Training ProgramT32EB001680 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BRUCE R ROSEN · 2003 to 2026
$3.8M
Deep learning for renal tumor characterizationR03CA249554 · NCI · RHODE ISLAND HOSPITAL · PI BAI, HARRISON · 2020 to 2021
$162k
Automatic Volumetric Treatment Response Assessment and Determination of Regional Genetic Characteristics in GlioblastomaF30CA239407 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHANG, KEN · 2019 to 2020
$101k
National Institute of General Medical Sciences of the National Institutes of Health which funds Advance Clinical and Translational Research U54GM115677NCI NIH HHS F30CA239407NCI NIH HHS R03CA249554NIBIB NIH HHS 5T32EB1680
6 · The paper itself

Abstract

objectivesThere currently lacks a noninvasive and accurate method to distinguish benign and malignant ovarian lesion prior to treatment. This study developed a deep learning algorithm that distinguishes benign from malignant ovarian lesion by applying a convolutional neural network on routine MR imaging.

methodsFive hundred forty-five lesions (379 benign and 166 malignant) from 451 patients from a single institution were divided into training, validation, and testing set in a 7:2:1 ratio. Model performance was compared with four junior and three senior radiologists on the test set.

resultsCompared with junior radiologists averaged, the final ensemble model combining MR imaging and clinical variables had a higher test accuracy (0.87 vs 0.64, p < 0.001) and specificity (0.92 vs 0.64, p < 0.001) with comparable sensitivity (0.75 vs 0.63, p = 0.407). Against the senior radiologists averaged, the final ensemble model also had a higher test accuracy (0.87 vs 0.74, p = 0.033) and specificity (0.92 vs 0.70, p < 0.001) with comparable sensitivity (0.75 vs 0.83, p = 0.557). Assisted by the model's probabilities, the junior radiologists achieved a higher average test accuracy (0.77 vs 0.64, Δ = 0.13, p < 0.001) and specificity (0.81 vs 0.64, Δ = 0.17, p < 0.001) with unchanged sensitivity (0.69 vs 0.63, Δ = 0.06, p = 0.302). With the AI probabilities, the junior radiologists had higher specificity (0.81 vs 0.70, Δ = 0.11, p = 0.005) but similar accuracy (0.77 vs 0.74, Δ = 0.03, p = 0.409) and sensitivity (0.69 vs 0.83, Δ = -0.146, p = 0.097) when compared with the senior radiologists.

conclusionsThese results demonstrate that artificial intelligence based on deep learning can assist radiologists in assessing the nature of ovarian lesions and improve their performance. KEY POINTS: • Artificial Intelligence based on deep learning can assess the nature of ovarian lesions on routine MRI with higher accuracy and specificity than radiologists. • Assisted by the deep learning model's probabilities, junior radiologists achieved better performance that matched those of senior radiologists.

Indexed as

Deep LearningOvarian CystsOvarian NeoplasmsArtificial IntelligenceFemaleHumansMagnetic Resonance ImagingNeural Networks, ComputerSensitivity and SpecificityDeep learningMagnetic resonance imagingOvarian neoplasms

Identifiers

PMID33052463
OpenAlexW3092126195

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.