Evidence map›Paper›PMID 33052330›Full record

ArticleResearch square2020

Homologies between SARS-CoV-2 and allergen proteins may direct T cell-mediated heterologous immune responses.

Kathrin Balz, Meng Chen, Abhinav Kaushik, Franz Cemic, Vanessa Heger, Harald Renz, Kari Nadeau, Chrysanthi Skevaki

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kathrin BalzInstitute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany.
Meng ChenSean N. Parker Center for Allergy and Asthma Research at Stanford University and Division of Pulmonary, Allergy & Critical Care Medicine, Stanford, CA, USA.
Abhinav KaushikSean N. Parker Center for Allergy and Asthma Research at Stanford University and Division of Pulmonary, Allergy & Critical Care Medicine, Stanford, CA, USA.
Franz CemicTH Mittelhessen, Department of Computer Science, University of Applied Sciences Gießen, Hessen, Deutschland.
Vanessa HegerTH Mittelhessen, Department of Computer Science, University of Applied Sciences Gießen, Hessen, Deutschland.
Harald RenzInstitute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany.
Kari NadeauSean N. Parker Center for Allergy and Asthma Research at Stanford University and Division of Pulmonary, Allergy & Critical Care Medicine, Stanford, CA, USA.
Chrysanthi SkevakiInstitute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany.
German Center for Lung Research · DEPulmonary and Allergy Associates · USTechnische Hochschule Mittelhessen · DE

Funding

T Cell Reagent Research for Monitoring T Cell in Food AllergyU01AI140498 · NIAID · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2018 to 2022
$1.8M
Effects of IgE Blockade on T Cells in Food AllergyR01AI140134 · NIAID · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2018 to 2021
$1.6M
NIAID NIH HHS R01 AI140134NIAID NIH HHS U01 AI140498
6 · The paper itself

Abstract

The outbreak of the new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a public health emergency. Asthma does not represent a risk factor for COVID-19 in several published cohorts. We hypothesized that the SARS-CoV-2 proteome contains T cell epitopes, which are potentially cross-reactive to allergen epitopes. We aimed at identifying homologous peptide sequences by means of two distinct complementary bioinformatics approaches. Pipeline 1 included prediction of MHC Class I and Class II epitopes contained in the SARS-CoV-2 proteome and allergens along with alignment and elaborate ranking approaches. Pipeline 2 involved alignment of SARS-CoV-2 overlapping peptides with known allergen-derived T cell epitopes. Our results indicate a large number of MHC Class I epitope pairs including known as well as

Identifiers

PMID33052330
PMCPMC7553154
OpenAlexW3092636216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.