Evidence map›Paper›PMID 33052114›Full record

ArticleJMIR medical informatics2020

Fueling Clinical and Translational Research in Appalachia: Informatics Platform Approach.

Alfred A Cecchetti, Niharika Bhardwaj, Usha Murughiyan, Gouthami Kothakapu, Uma Sundaram

Abstract read
In one paragraph

Article in JMIR medical informatics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Gaps in artificial intelligence research for rural health in the United States: a scoping review.Journal of the American Medical Informatics Association : JAMIA · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alfred A CecchettiDepartment of Clinical and Translational Science, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, United States.ORCID https://orcid.org/0000-0002-6249-7310
Niharika BhardwajDepartment of Clinical and Translational Science, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, United States.ORCID https://orcid.org/0000-0001-7897-8277
Usha MurughiyanDepartment of Clinical and Translational Science, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, United States.ORCID https://orcid.org/0000-0003-3304-2920
Gouthami KothakapuDepartment of Clinical and Translational Science, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, United States.ORCID https://orcid.org/0000-0003-1047-6232
Uma SundaramDepartment of Clinical and Translational Science, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, United States.ORCID https://orcid.org/0000-0002-9322-6740

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
Regulation of Tight Junction Molecular Composition by Na/K-ATPaseP20GM121299 · NIGMS · MARSHALL UNIVERSITY · PI SUNDARAM, UMA · 2018 to 2022
$10.6M
REGULATION OF INTESTINAL NA ABSORPTIONR01DK067420 · NIDDK · WEST VIRGINIA UNIVERSITY · PI SUNDARAM, UMA · 2004 to 2016
$3.2M
Regulation of amino acid absorption in the mammalian small intestineR01DK108054 · NIDDK · MARSHALL UNIVERSITY · PI SUNDARAM, UMA · 2016 to 2020
$2.4M
Regulation of intestinal NaCl absorptionI01BX003443 · VA · HUNTINGTON VETERANS AFFAIRS MED CTR · PI Uma Sundaram · 2017 to 2026
–
BLRD VA I01 BX003443NIDDK NIH HHS R01 DK067420NIDDK NIH HHS R01 DK108054NIGMS NIH HHS P20 GM121299NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

backgroundThe Appalachian population is distinct, not just culturally and geographically but also in its health care needs, facing the most health care disparities in the United States. To meet these unique demands, Appalachian medical centers need an arsenal of analytics and data science tools with the foundation of a centralized data warehouse to transform health care data into actionable clinical interventions. However, this is an especially challenging task given the fragmented state of medical data within Appalachia and the need for integration of other types of data such as environmental, social, and economic with medical data.

objectiveThis paper aims to present the structure and process of the development of an integrated platform at a midlevel Appalachian academic medical center along with its initial uses.

methodsThe Appalachian Informatics Platform was developed by the Appalachian Clinical and Translational Science Institute's Division of Clinical Informatics and consists of 4 major components: a centralized clinical data warehouse, modeling (statistical and machine learning), visualization, and model evaluation. Data from different clinical systems, billing systems, and state- or national-level data sets were integrated into a centralized data warehouse. The platform supports research efforts by enabling curation and analysis of data using the different components, as appropriate.

resultsThe Appalachian Informatics Platform is functional and has supported several research efforts since its implementation for a variety of purposes, such as increasing knowledge of the pathophysiology of diseases, risk identification, risk prediction, and health care resource utilization research and estimation of the economic impact of diseases.

conclusionsThe platform provides an inexpensive yet seamless way to translate clinical and translational research ideas into clinical applications for regions similar to Appalachia that have limited resources and a largely rural population.

Indexed as

Appalachian regiondata miningdata sciencedata visualizationdata warehousingelectronic health recordshealth care disparitiesmachine learningmedical informatics

Identifiers

PMID33052114
PMCPMC7593861

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.