Evidence map›Paper›PMID 33052071›Full record

ArticleAmerican journal of physiology. Cell physiology2021

Structural and functional characterization of engineered bifunctional fusion proteins of CD39 and CD73 ectonucleotidases.

Elizabeth H Zhong, Carola Ledderose, Paola De Andrade Mello, Keiichi Enjyoji, Justin Mark Lunderberg, Wolfgang Junger, Simon C Robson

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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  4. Apoptotic Vesicles Attenuate Acute Lung InjuryInternational journal of nanomedicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elizabeth H ZhongDepartment of Anesthesia, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
Carola LedderoseDepartment of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
Paola De Andrade MelloDepartment of Anesthesia, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
Keiichi EnjyojiDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
Justin Mark LunderbergDepartment of Anesthesia, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
Wolfgang JungerDepartment of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
Simon C RobsonDepartment of Anesthesia, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-6374-0194
Beth Israel Deaconess Medical Center · US

Funding

Metabolic and purinergic immune regulationR35GM136429 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JUNGER, WOLFGANG G · 2020 to 2024
$2.3M
Role of purinergic signaling in pediatric multi-organ failureR01HD098363 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JUNGER, WOLFGANG G · 2019 to 2023
$2.0M
Immunomodulatory effects of bilirubin are mediated through aryl hydrocarbon receptor, O2 and purinergic pathwaysR01DK108894 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LONGHI, MARIA SERENA · 2017 to 2021
$2.0M
Directed Purinergic Signaling as Immunotherapy in LeukemiaR21CA221702 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI AVIGAN, DAVID E., ROBSON, SIMON C. · 2018 to 2019
$413k
HHS | NIH | National Cancer Institute (NCI) CA221702HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK108894NCI NIH HHS R21 CA221702NICHD NIH HHS R01 HD098363NIDDK NIH HHS R01 DK108894NIGMS NIH HHS R35 GM136429
6 · The paper itself

Abstract

Extracellular diphosphate and triphosphate nucleotides are released from activated or injured cells to trigger vascular and immune P

Indexed as

Protein Engineering5'-NucleotidaseAdenine NucleotidesAnti-Inflammatory AgentsApyraseGPI-Linked ProteinsHEK293 CellsHumansHydrogen-Ion ConcentrationHydrolysisKineticsPlatelet AggregationPlatelet Aggregation InhibitorsProtein ConformationRecombinant Fusion ProteinsSignal Transduction5'-NucleotidaseAdenine NucleotidesAnti-Inflammatory AgentsApyraseENTPD1 protein, humanGPI-Linked ProteinsNT5E protein, humanPlatelet Aggregation InhibitorsRecombinant Fusion Proteinsbifunctional fusionectonucleotidaseinflammationplatelet aggregationpurinergic signaling

Identifiers

PMID33052071
PMCPMC7846972
OpenAlexW3091915607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.