Evidence map›Paper›PMID 33051891›Full record

ReviewMuscle & nerve2021

Muscle ultrasound: Present state and future opportunities.

Juerd Wijntjes, Nens van Alfen

Registry-linked trialAbstract readReview
In one paragraph

Review in Muscle & nerve, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05692349 (Role of Magnetic Resonance Imaging and Ultrasonography in Evaluation of Muscle Diseases), which is not on this map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05692349 unknown statusnot on this mapstarted 2023, after this paper: background citation

Role of Magnetic Resonance Imaging and Ultrasonography in Evaluation of Muscle Diseases

TypeobservationalSponsorAssiut UniversityRan2023 to 2024Enrolled36ConditionsCongenital Myopathy, Acquired Myopathy, MyositisArmsMRI
3 · Its place in the literature

Who cites it

90 citing papers in PubMed.

  1. Trial
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Optoacoustic muscle imaging.Journal of neuromuscular diseases · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. A neuromuscular clinician's primer on machine learning.Journal of neuromuscular diseases · 2026
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Observational

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Juerd WijntjesDepartment of Neurology and Clinical Neurophysiology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.
Nens van AlfenDepartment of Neurology and Clinical Neurophysiology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Muscle ultrasound is a valuable addition to the neuromuscular toolkit in both the clinic and research settings, with proven value and reliability. However, it is currently not fulfilling its full potential in the diagnostic care of patients with neuromuscular disease. This review highlights the possibilities and pitfalls of muscle ultrasound as a diagnostic tool and biomarker, and discusses challenges to its widespread implementation. We expect that limitations in visual image interpretation, posed by user inexperience, could be overcome with simpler scoring systems and the help of deep-learning algorithms. In addition, more information should be collected on the relation between specific neuromuscular disorders, disease stages, and expected ultrasound abnormalities, as this will enhance specificity of the technique and enable the use of muscle ultrasound as a biomarker. Quantified muscle ultrasound gives the most sensitive results but is hampered by the need for device-specific reference values. Efforts in creating dedicated muscle ultrasound systems and artificial intelligence to help with image interpretation are expected to improve usability. Finally, the standard inclusion of muscle and nerve ultrasound in neuromuscular teaching curricula and guidelines will facilitate further implementation in practice. Our hope is that this review will help in unleashing muscle ultrasound's full potential.

Indexed as

UltrasonographyAlgorithmsArtificial IntelligenceHumansMuscle, SkeletalNeuromuscular DiseasesReference Valuesbiomarkerdiagnostic screeningimplementationmuscle ultrasoundneuromuscular ultrasound

Identifiers

PMID33051891
PMCPMC8048972

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.