Trial reportJournal of surgical oncology2021
First-year complications after immediate breast reconstruction with a biological and a synthetic mesh in the same patient: A randomized controlled study.
Trial report in Journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02985073 (The Gothenburg TIGR/Veritas® Study - A Comparison Between Biological), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Gothenburg TIGR/Veritas® Study - A Comparison Between Biological (Veritas®) vs Non Biological Mesh (TIGR®) in Immediate Breast Reconstruction
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Litigation meets evidence: a novel approach to understanding preventable complications in breast reconstruction.BMC surgery · 2025Pooled it
- The Usage of Mesh and Relevant Prognosis in Implant Breast Reconstruction Surgery: A Meta-analysis.Aesthetic plastic surgery · 2024Pooled it
- Effect of Immediate Implant-Based Breast Reconstruction After Mastectomy With and Without Acellular Dermal Matrix Among Women With Breast Cancer: A Randomized Clinical Trial.JAMA network open · 2021Trial
- First-year complications after immediate breast reconstruction with a biological and a synthetic mesh in the same patient: A randomized controlled study.Journal of surgical oncology · 2021Trial
- Short-term Outcomes of Polydioxanone Synthetic Mesh in 2-stage Breast Reconstruction: A Single-Center Comparative Study.Aesthetic surgery journal · 2026Article
- Clinical safety and breast symmetry after injectable acellular dermal fibers reconstruction: an MR-based volumetric study.Gland surgery · 2026Article
- The current status and hot topics of endoscopic techniques in breast cancer surgery: a global bibliometric and visualization analysis (1999-2024).Gland surgery · 2026Article
- Abdominal Wall Reinforcement Using OviTex after Deep Inferior Epigastric Perforator Flap.Journal of reconstructive microsurgery · 2026Article
- Techniques for Retaining the Inframammary Fold in Implant-Based Reconstructive Breast Surgery.European journal of breast health · 2025Article
- Article
- Polypropylene Mesh in Nipple-Sparing Mastectomy and Immediate Implant-based Breast Reconstruction in Vietnamese Early Breast Cancer Patients: Safe and Feasible.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- The Effects of Systemic Tranexamic Acid Administration on Drainage Volume, Duration of Drain Placement, and Length of Hospital Stay in Skin- and Nipple-Sparing Mastectomies with Immediate Expander-Based Breast Reconstruction.Journal of clinical medicine · 2024Article
- Article
- A Systematic Review and Meta-Analysis of Synthetic Mesh Outcomes in Alloplastic Breast Reconstruction.Aesthetic surgery journal. Open forum · 2024Review
- Comparing Complications of Biologic and Synthetic Mesh in Breast Reconstruction: A Systematic Review and Network Meta-Analysis.Archives of plastic surgery · 2023Article
- Acellular dermal matrix in reconstructive surgery: Applications, benefits, and cost.Frontiers in transplantation · 2023Review
- Article
- Seroma after Simple Mastectomy in Breast Cancer-The Role of CD4+ T Helper Cells and the Evidence as a Possible Specific Immune Process.International journal of molecular sciences · 2022Article
- Novel three-dimensional acellular dermal matrix for prepectoral breast reconstruction: First year in review with BRAXONFrontiers in surgery · 2022Article
- Pliable, Scalable, and Degradable Scaffolds with Varying Spatial Stiffness and Tunable Compressive Modulus Produced by Adopting a Modular Design Strategy at the Macrolevel.ACS polymers Au · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundEven though meshes and matrices are widely used in breast reconstruction, there is little high-quality scientific evidence for their risks and benefits. The aim of this study was to compare first-year surgical complication rates in implant-based immediate breast reconstruction with a biological mesh with that of a synthetic mesh, in the same patient.
methodsThis study is a clinical, randomized, prospective trial. Patients operated on with bilateral mastectomy and immediate breast reconstruction were randomized to biological mesh on one side and synthetic mesh on the other side.
resultsA total of 48 breasts were randomized. As the synthetically and the biologically reconstructed breasts that were compared belonged to the same woman, systemic factors were exactly the same in the two groups. The most common complication was seroma formation with a frequency of 38% in the biological group and 3.8% in the synthetical group (p = .011). A higher frequency of total implant loss could be seen in the biologic mesh group (8.5% vs. 2%), albeit not statistically significant (p = .083).
conclusionsIn the same patient, a synthetic mesh seems to yield a lower risk for serious complications, such as implant loss, than a biological mesh.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.