Evidence map›Paper›PMID 33051857›Full record

ArticleEating and weight disorders : EWD2021

White matter microstructural differences in underweight adolescents with anorexia nervosa and a preliminary longitudinal investigation of change following short-term weight restoration.

Kristi R Griffiths, Beatriz Martin Monzon, Sloane Madden, Michael R Kohn, Stephen Touyz, Perminder S Sachdev, Simon Clarke, Nasim Foroughi, Phillipa Hay

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Article in Eating and weight disorders : EWD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristi R Griffiths *Brain Dynamics Centre, The Westmead Institute for Medical Research, The University of Sydney, 176 Hawkesbury Rd, Westmead, Sydney, NSW, 2145, Australia. Kristi.griffiths@sydney.edu.au.ORCID http://orcid.org/0000-0002-7108-2272
Beatriz Martin Monzon *Translational Health Research Institute (THRI), School of Medicine, Western Sydney University, Sydney, Australia.
Sloane MaddenSchool of Medicine, University of Sydney, Sydney, Australia.
Michael R KohnCentre for Research Into Adolescents' Health (CRASH), University of Sydney, Sydney, Australia.
Stephen TouyzClinical Psychology Unit, School of Psychology, University of Sydney, Sydney, Australia.
Perminder S SachdevCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, and Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, Australia.
Simon ClarkeCentre for Research Into Adolescents' Health (CRASH), University of Sydney, Sydney, Australia.
Nasim ForoughiTranslational Health Research Institute (THRI), School of Medicine, Western Sydney University, Sydney, Australia.
Phillipa HayTranslational Health Research Institute (THRI), School of Medicine, Western Sydney University, Sydney, Australia.

Funding

National Health and Medical Research Council 1122842
6 · The paper itself

Abstract

purposeAnorexia nervosa (AN) affects approximately 2.9% of females and has the highest mortality rate among all psychiatric disorders. Despite several advances, the neurobiology of this disorder is still not well understood. Several studies have reported abnormalities in the white matter, but it is not know if these are disease-related or secondary to undernutrition. This study aimed to further our understanding of white matter pathology using diffusion-weighted imaging in underweight adolescents with AN, and to examine changes occurring after short-term weight restoration.

methodsAnalyses were conducted on diffusion-weighted imaging from 24 female adolescents with AN and 17 age- and gender-matched healthy controls (HC), aged 14-19 years. Groups were compared on fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) using tract-based spatial statistics analysis and DTI measures were correlated with eating disorder examination questionnaire (EDE-Q) subscales and body mass index (BMI). Preliminary repeated-measure analyses were also conducted on eight participants after short-term weight restoration (median 41 days).

resultsWidespread increases in MD of up to 9% were found in underweight AN relative to HC, particularly in the corpus callosum. This was associated with both increased AD and RD, suggestive of dys- or de-myelination. There were no significant group differences in FA, and no significant correlations between DTI measures, BMI or EDE-Q subscale score. Weight restoration therapy significantly reduced MD, to levels significantly lower than HC, but did not consistently alter FA across individuals.

conclusionsWhite matter microstructure is significantly altered in female adolescents with AN, with preliminary longitudinal data suggesting that it may be reversible with short-term weight restoration. LEVEL OF EVIDENCE: Level III: evidence obtained from well-designed cohort or case-control analytic studies.

Indexed as

Anorexia NervosaWhite MatterAdolescentAnisotropyDiffusion Tensor ImagingFemaleHumansThinnessAdolescentAnorexia nervosaFractional anisotropyLongitudinalMean diffusivityWhite matter

Identifiers

PMID33051857

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.