Evidence map›Paper›PMID 33051781›Full record

ArticleInflammopharmacology2021

Quercetin inhibits caerulein-induced acute pancreatitis through regulating miR-216b by targeting MAP2K6 and NEAT1.

Bo Sheng, Lei Zhao, Xuefeng Zang, Jie Zhen, Yang Liu, Weishuai Bian, Wei Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bo ShengDepartment of Intensive Care Unit, Beijing Shijitan Hospital Affiliated to Capital Medical University, No. 10 Tieyilu Street, Beijing, 100038, People's Republic of China.
Lei ZhaoDepartment of Intensive Care Unit, Beijing Shijitan Hospital Affiliated to Capital Medical University, No. 10 Tieyilu Street, Beijing, 100038, People's Republic of China.
Xuefeng ZangDepartment of Intensive Care Unit, Beijing Shijitan Hospital Affiliated to Capital Medical University, No. 10 Tieyilu Street, Beijing, 100038, People's Republic of China.
Jie ZhenDepartment of Intensive Care Unit, Beijing Shijitan Hospital Affiliated to Capital Medical University, No. 10 Tieyilu Street, Beijing, 100038, People's Republic of China.
Yang LiuDepartment of Intensive Care Unit, Beijing Shijitan Hospital Affiliated to Capital Medical University, No. 10 Tieyilu Street, Beijing, 100038, People's Republic of China.
Weishuai BianDepartment of Intensive Care Unit, Beijing Shijitan Hospital Affiliated to Capital Medical University, No. 10 Tieyilu Street, Beijing, 100038, People's Republic of China.
Wei ChenDepartment of Intensive Care Unit, Beijing Shijitan Hospital Affiliated to Capital Medical University, No. 10 Tieyilu Street, Beijing, 100038, People's Republic of China. wei.chen_cmu@hotmail.com.ORCID http://orcid.org/0000-0002-0665-1184
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute pancreatitis (AP) is a common acute abdominal disease with high mortality and mortality rates. Increasing evidences clarified that Traditional Chinese Medicine (TCM) adjuvant therapy for AP can be used and it gives a positive effect. Quercetin (3,3',4',5,7-pentahydroxyflavone, QE) is a type of flavone compound with positive effect on cancer and inflammation prevention. The current study aims to identify the effect of QE on AP and potential molecular effect. In this case, caerulein (CAE) induced AP cell and mice model were used. QE alleviated inflammatory mediators TNF-α, IL-6, and IL-10 in experiments. In addition, miR-216b was increased based on QE treatment. In further study, MAP2K6 of p38/MAPK signaling pathway was identified as a direct target of miR-216b, and QE inhibited p38/MAPK signaling pathway through up-regulating miR-216b. Our study also first confirmed that long non-coding RNA NEAT1 is a direct target of miR-216b and can be suppressed by QE. Because of the target, NEAT1, miR-216b, and MAP2K6 formed a competitive endogenous RNA (ceRNA) network. Besides direct target mediated by QE, it also decreased TNF-α which down-regulated TRAF2 and MAP3K5 located on upstream of p38/MAPK signaling and formed a feedback loop. In conclusion, QE has a protective effect on AP through inhibiting p38/MAPK signaling pathway by up-regulating miR-216b and suppressing TNF-α.

Indexed as

AnimalsCell LineCeruletideDisease Models, AnimalDown-RegulationMAP Kinase Kinase 6MiceMice, Inbred C57BLMicroRNAsp38 Mitogen-Activated Protein KinasesPancreasPancreatitisQuercetinRatsRNA, Long NoncodingSignal TransductionCeruletideMap2k6 protein, mouseMAP Kinase Kinase 6MicroRNAsMIRN216 microRNA, mouseNEAT1 long non-coding RNA, mousep38 Mitogen-Activated Protein KinasesQuercetinRNA, Long NoncodingAcute pancreatitisMAP2K6miR-216bNEAT1p38/MAPK signalingQuercetin

Identifiers

PMID33051781
OpenAlexW3091984732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.