Evidence map›Paper›PMID 33051736›Full record

ArticleEuropean radiology2021

Chest radiograph at admission predicts early intubation among inpatient COVID-19 patients.

Nicholas Xiao, John G Cooper, Jacqueline M Godbe, Meagan A Bechel, Michael B Scott, Edward Nguyen, Danielle M McCarthy, Samir Abboud, Bradley D Allen, Nishant D Parekh

Abstract read
In one paragraph

Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Lung Ultrasound Score in COVID-19 Patients Correlates with POThe western journal of emergency medicine · 2024
    Pooled it
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  10. Observational
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  14. Role of chest radiograph in predicting the need for ventilator support in COVID-19 patients.African journal of thoracic and critical care medicine · 2022
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  15. Article
  16. Still a role for the chest radiograph - humble but helpful!African journal of thoracic and critical care medicine · 2022
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  17. Review
  18. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicholas Xiao *Department of Radiology, Division of Chest and Cardiovascular Imaging, Northwestern University, 676 N. St. Clair, Suite 800, Chicago, IL, 60611, USA. n-xiao@northwestern.edu.ORCID http://orcid.org/0000-0002-9878-512X
John G Cooper *Department of Radiology, Division of Chest and Cardiovascular Imaging, Northwestern University, 676 N. St. Clair, Suite 800, Chicago, IL, 60611, USA.
Jacqueline M GodbeDepartment of Radiology, Division of Chest and Cardiovascular Imaging, Northwestern University, 676 N. St. Clair, Suite 800, Chicago, IL, 60611, USA.
Meagan A BechelDepartment of Radiology, Division of Chest and Cardiovascular Imaging, Northwestern University, 676 N. St. Clair, Suite 800, Chicago, IL, 60611, USA.
Michael B ScottDepartment of Radiology, Division of Chest and Cardiovascular Imaging, Northwestern University, 676 N. St. Clair, Suite 800, Chicago, IL, 60611, USA.
Edward NguyenDepartment of Radiology, Division of Chest and Cardiovascular Imaging, Northwestern University, 676 N. St. Clair, Suite 800, Chicago, IL, 60611, USA.
Danielle M McCarthyDepartment of Emergency Medicine, Northwestern University, Chicago, IL, USA.
Samir AbboudDepartment of Radiology, Division of Emergency Radiology, Northwestern University, Chicago, IL, USA.
Bradley D AllenDepartment of Radiology, Division of Chest and Cardiovascular Imaging, Northwestern University, 676 N. St. Clair, Suite 800, Chicago, IL, 60611, USA.
Nishant D ParekhDepartment of Radiology, Division of Chest and Cardiovascular Imaging, Northwestern University, 676 N. St. Clair, Suite 800, Chicago, IL, 60611, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0M
Medical Scientist Training ProgramT32GM144295 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ALAN R HAUSER · 2022 to 2026
$9.1M
NIGMS NIH HHS T32 GM008152NIGMS NIH HHS T32 GM144295
6 · The paper itself

Abstract

objectiveThe 2019 Coronavirus (COVID-19) results in a wide range of clinical severity and there remains a need for prognostic tools which identify patients at risk of rapid deterioration and who require critical care. Chest radiography (CXR) is routinely obtained at admission of COVID-19 patients. However, little is known regarding correlates between CXR severity and time to intubation. We hypothesize that the degree of opacification on CXR at time of admission independently predicts need and time to intubation.

methodsIn this retrospective cohort study, we reviewed COVID-19 patients who were admitted to an urban medical center during March 2020 that had a CXR performed on the day of admission. CXRs were divided into 12 lung zones and were assessed by two blinded thoracic radiologists. A COVID-19 opacification rating score (CORS) was generated by assigning one point for each lung zone in which an opacity was observed. Underlying comorbidities were abstracted and assessed for association.

resultsOne hundred forty patients were included in this study and 47 (34%) patients required intubation during the admission. Patients with CORS ≥ 6 demonstrated significantly higher rates of early intubation within 48 h of admission and during the hospital stay (ORs 24 h, 19.8, p < 0.001; 48 h, 28.1, p < 0.001; intubation during hospital stay, 6.1, p < 0.0001). There was no significant correlation between CORS ≥ 6 and age, sex, BMI, or any underlying cardiac or pulmonary comorbidities.

conclusionsCORS ≥ 6 at the time of admission predicts need for intubation, with significant increases in intubation at 24 and 48 h, independent of comorbidities. KEY POINTS: • Chest radiography at the time of admission independently predicts time to intubation within 48 h and during the hospital stay in COVID-19 patients. • More opacities on chest radiography are associated with several fold increases in early mechanical ventilation among COVID-19 patients. • Chest radiography is useful in identifying COVID-19 patients whom may rapidly deteriorate and help inform clinical management as well as hospital bed and ventilation allocation.

Indexed as

COVID-19HumansInpatientsIntubation, IntratrachealRadiography, ThoracicRetrospective StudiesSARS-CoV-2COVID-19IntubationPrognosisRadiography

Identifiers

PMID33051736
PMCPMC7553374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.