ReviewAesthetic plastic surgery2021
A Review of Complications Due to the Use of Botulinum Toxin A for Cosmetic Indications.
Review in Aesthetic plastic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Adverse Events in Nonsurgical Facial Aesthetic Procedures: A Systematic Review and Meta-Analysis.Oral diseases · 2026Pooled it
- Complications of Cosmetic Botulinum Toxin A Injections to the Upper Face: A Systematic Review and Meta-Analysis.Aesthetic surgery journal · 2022Pooled it
- The Adjunctive Role of Botulinum Toxin A in Wound Healing and Scar Management.Aesthetic plastic surgery · 2026Review
- Skin Temperature as a Marker of Vasomotor Response and Restoration of Blood Flow After Aesthetic Botulinum Toxin Therapy in the Forehead.Life (Basel, Switzerland) · 2026Article
- Transverse Facial Artery Morphometry Based on Head Dimensions and Palpable Anatomical Landmarks.Aesthetic surgery journal · 2026Article
- Long-term neuromuscular alterations during botulinum toxin treatment for chronic migraine.Clinical neurophysiology practice · 2026Article
- Exploring the Therapeutic Potential of Botulinum Toxin in Treating Post-Acne Sequelae: A Critical Review.Clinical, cosmetic and investigational dermatology · 2026Review
- Monitoring complications of botulinum toxin in community practice: A pharmacological study.Bioinformation · 2026Article
- Observational
- Article
- A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of OBI-858 for the Treatment of Moderate-to-Severe Glabellar Lines.Dermatology and therapy · 2025Article
- Dysphagia and Muscle Weakness Caused by Botulinum Toxin Poisoning after Cosmetic Injection: Three Case Reports and Clinical Warnings.Dysphagia · 2025Review
- Facial Injectable Fillers in Aesthetic Medicine: Clinical Applications and Safety Strategies.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Engineered Exosomes Complexed with Botulinum Toxin Type A for Enhanced Anti-Aging Effects on Skin.Biology · 2025Article
- Main facial anatomical concerns of dentists to perform botox injections.Journal of clinical and experimental dentistry · 2025Article
- Article
- Observation of Safety and Efficacy of Botulinum Toxin Type A in the Treatment of Tear Troughs and Mild Yelid Bags.Journal of cosmetic dermatology · 2025Article
- Effect of Intensive Face Yoga on Facial Muscles Tonus, Stiffness, and Elasticity in Middle-Aged Women: A Pre-Experimental Clinical Trial.Medicina (Kaunas, Lithuania) · 2025Article
- A Rare Case of Delayed-Onset Hypersensitivity Reaction and Complete Secondary Treatment Failure Following Repeated Cosmetic Botulinum Toxin Type A Injections.Journal of cosmetic dermatology · 2025Article
- Wearable Temperature Sensor Enhanced Volatilomics Technique for Swift and Convenient Detection of Latrogenic Botulism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBotulinum toxin A (botulinum toxin A) was found to provide a wide variety of therapeutic and aesthetic benefits as one of the most potent toxins in the world. Injectable remedies, including soft tissue fillers and botulinum toxin, have become very common in wrinkling and face rejuvenation management. While these methods of treatment are relatively safe, serious side effects can occur. In this review, the complications of BoNTA are highlighted.
methodsA literature research considered published journal articles (clinical trials or scientific reviews). Electronic databases (PubMed, Scopus, Science Direct) were searched using key terms, and for identification of additional relevant studies, reference lists have also been examined. Only articles published in English were included in this review with a time restriction from 2000 to 2020.
resultsThere are various injection-related adverse effects associated (AE) with botulinum toxins such as erythema, oedema, pain, ptosis of eyelid or brow and ecchymosis. The overall majority of adverse events identified are mild and temporary.
conclusionAs the use of toxins becomes increasingly more common, adverse events can be expected to increase as well. The practitioners need to be aware of such AEs, and the patients should be informed of these before undertaking such procedures. LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.