ArticleEuropean journal of pediatrics2021
Lymphatic malformations in children: treatment outcomes of sclerotherapy in a large cohort.
Article in European journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- High-Frequency Ultrasound-Guided Treatment of a Head and Neck Lymphatic Malformation.Healthcare (Basel, Switzerland) · 2026Article
- A national multicenter analysis of hospitalization admission records for lymphatic malformation in China from 2016 to 2023.BMC pediatrics · 2026Article
- Sclerotherapy combined with sirolimus for the treatment of complex cervicofacial lymphatic malformations in infants: avoiding the need for tracheostomy.Journal of neurointerventional surgery · 2026Article
- Article
- Predictive Factors for Response to Percutaneous Bleomycin in Lymphatic-Venous Malformations of the Head and Neck.Journal of clinical medicine · 2025Article
- Be familiar with benign pediatric head and neck lesions! Image interpretation guides to overcome your weakness.Japanese journal of radiology · 2025Review
- Sclerothrapy of giant lymphatic malformation in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Ultrasound-Guided Percutaneous Sclerotherapy With Bleomycin for Management of Infantile Subcutaneous Hemangioma: A Case Report.Clinical case reports · 2025Article
- Multidisciplinary management of extensive cervical lymphatic malformations and epiglottic cyst in a neonate: a case report and review of perioperative strategies.Frontiers in pediatrics · 2025Article
- A 14-year single-center experience evaluating sclerotherapy efficacy in lymphatic malformations.Journal of vascular surgery. Venous and lymphatic disorders · 2024Article
- Outcome of bleomycin electrosclerotherapy of slow-flow malformations in adults and children.European radiology · 2024Article
- Congenital Vascular Malformations in Children: From Historical Perspective to a Multidisciplinary Approach in the Modern Era-A Comprehensive Review.Children (Basel, Switzerland) · 2024Review
- Case report: A rare case of multifocal, combined lymphatic-venous malformation.Frontiers in medicine · 2024Article
- Health-related quality of life in children with congenital vascular malformations.European journal of pediatrics · 2023Article
- Rapid lymphatic malformation expansion: Imaging, association with asymptomaticRadiology case reports · 2023Article
- The rare complication of vascular malformations of the limb after sclerotherapy: a report of 3 cases and brief literature review.BMC pediatrics · 2023Article
- A nomogram for predicting sclerotherapy response for treatment of lymphatic malformations in children.European journal of medical research · 2022Article
- Sclerotherapy in Lymphatic Malformations with Intralesional Hemorrhage: A Retrospective Comparison with Non-Hemorrhagic Lymphatic Malformations.Clinical, cosmetic and investigational dermatology · 2022Article
- Cystic hygroma of the neck - case report.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
- Bleomycin-Electrosclerotherapy in the treatment of superficial slow-flow vascular malformations of head and neck.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This retrospective study examines the outcomes of sclerotherapy in children with (veno)lymphatic malformations who received sclerotherapy between 2011 and 2016 (116 children, 234 procedures). Complication severity was classified using the Society of Interventional Radiology classification. Clinical response was rated on a scale of 0 (no change) to 3 (good improvement). The sclerosants used were bleomycin (n = 132; 56%), lauromacrogol (n = 42; 18%), doxycycline (n = 15; 6%), ethanol (n = 12; 5%), or a combination (n = 33; 14%). Four major and 25 minor complications occurred without significant differences between the agents. The median response rate per procedure was 2-some improvement-for all sclerosants. However, in pure LMs (67%), bleomycin and a combination of agents resulted in the best clinical response. On patient level, all had some or good clinical response. Mixed macrocystic and microcystic lesions showed a significantly lower clinical response (median 2 versus 3; p = 0.023 and p = 0.036, respectively) and required significantly more procedures (median 2 versus 1; p = 0.043 and p = 0.044, respectively) compared with lesions with one component.Conclusion: Sclerotherapy for (V)LMs in children is safe and effective. Bleomycin is the most frequently used agent in this clinic and seemed most effective for pure LMs. Mixed macrocystic and microcystic lesions are most difficult to treat effectively. What is Known: • A variety of agents can be used for sclerotherapy of lymphatic malformations in children. • Macrocystic lesions have favorable outcomes compared with microcystic and mixed lesions. What is New: • Bleomycin and a combination of agents seem to be most effective to treat lymphatic malformations in children. • Mixed macrocystic and microcystic lesions are more difficult to treat effectively compared with lesions with either one of these components.
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