Evidence map›Paper›PMID 33051377›Full record

ArticlemSystems2020

Reduced Independence in Daily Living Is Associated with the Gut Microbiome in People with HIV and HCV.

Bryn C Taylor, Kelly C Weldon, Ronald J Ellis, Donald Franklin, Daniel McDonald, Gregory Humphrey, MacKenzie Bryant, Julia Toronczak, Tara Schwartz, Jennifer Iudicello and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Bryn C Taylor *Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0002-4957-5417
Kelly C Weldon *Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.
Ronald J EllisDepartment of Neurosciences, HIV Neurobehavioral Research Center, University of California San Diego, La Jolla, California, USA.
Donald FranklinDepartment of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California, USA.
Daniel McDonaldDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA.
Gregory HumphreyDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA.
MacKenzie BryantDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA.
Julia ToronczakDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA.
Tara SchwartzDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA.
Jennifer IudicelloDepartment of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California, USA.
Robert HeatonDepartment of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California, USA.
Igor GrantDepartment of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California, USA.
Sara GianellaDivision of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0002-9927-0849
Scott LetendreDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
Austin SwaffordCenter for Microbiome Innovation, University of California San Diego, La Jolla, California, USA.
Pieter C DorresteinCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.
Rob KnightCenter for Microbiome Innovation, University of California San Diego, La Jolla, California, USA robknight@ucsd.edu.ORCID https://orcid.org/0000-0002-0975-9019
University of California San Diego · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4M
Project 4 - Mechanistic studies on the role of the gut microbiome in models for Alzheimer's diseaseU19AG063744 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Rima F Kaddurah-Daouk · 2019 to 2026
$54.1M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
Identification of Biomarkers of CNS injury and resilience related to HIV-1 and MethamphetamineR01DA047879 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IUDICELLO, JENNIFER E, LETENDRE, SCOTT L · 2018 to 2022
$3.7M
NCATS NIH HHS UL1 TR001442NIAID NIH HHS P30 AI036214NIA NIH HHS U19 AG063744NIDA NIH HHS R01 DA047879NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

Alterations in the gut microbiome are associated with neurocognition and related disorders, including in the context of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection. However, the connection between the gut microbiome and cognitive decline, gauged by increased dependence in instrumental activities of daily living (IADL), remains largely unexplored in the context of these diseases. Here we characterized the gut microbiome using 16S rRNA amplicon sequencing and untargeted metabolomics with liquid chromatography-mass spectrometry from 347 people with HIV, HIV and HCV, or neither, all of whom underwent a comprehensive neuropsychiatric assessment. We observed that IADL-dependent and -independent HIV-monoinfected (HIV-positive [HIV+]/HCV-negative [HCV-]) and coinfected (HIV+/HCV+) individuals have distinct gut microbiomes. Moreover, we found that dependent individuals with HIV or HIV and HCV were enriched in

Indexed as

gut-brain axisgut microbiomehepatitis C virushuman immunodeficiency virusIADL

Identifiers

PMID33051377
PMCPMC7567581
OpenAlexW3092292139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.