Evidence map›Paper›PMID 33051372›Full record

ArticlemBio2020

Aspergillus fumigatus G-Protein Coupled Receptors GprM and GprJ Are Important for the Regulation of the Cell Wall Integrity Pathway, Secondary Metabolite Production, and Virulence.

Aílton Pereira da Costa Filho, Guilherme Thomaz Pereira Brancini, Patrícia Alves de Castro, Clara Valero, Jaire Alves Ferreira Filho, Lilian Pereira Silva, Marina Campos Rocha, Iran Malavazi, João Guilherme de Moraes Pontes, Taícia Fill and 7 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Molecular mechanisms drivingFrontiers in molecular biosciences · 2026
    Review
  3. Computational Approaches for Discovering Virulence Factors inJournal of fungi (Basel, Switzerland) · 2025
    Review
  4. mBio · 2025
    Article
  5. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  6. Fungal Stress Responses and the Importance of GPCRs.Journal of fungi (Basel, Switzerland) · 2025
    Review
  7. Journal of fungi (Basel, Switzerland) · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Journal of fungi (Basel, Switzerland) · 2021
    Article
  13. Genetic Interactions BetweenFrontiers in fungal biology · 2021
    Article
  14. Review
  15. Heterotrimeric G-protein signalers and RGSs inPathogens (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Aílton Pereira da Costa FilhoFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Guilherme Thomaz Pereira BranciniFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Patrícia Alves de CastroFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Clara ValeroFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Jaire Alves Ferreira FilhoFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Lilian Pereira SilvaFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Marina Campos RochaDepartamento de Genética e Evolução, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos, Brazil.
Iran MalavaziDepartamento de Genética e Evolução, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos, Brazil.ORCID 0000-0002-4526-4961
João Guilherme de Moraes PontesInstituto de Química, Universidade de Campinas, Campinas, São Paulo, Brazil.
Taícia FillInstituto de Química, Universidade de Campinas, Campinas, São Paulo, Brazil.
Roberto Nascimento SilvaFaculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Fausto AlmeidaFaculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Jacob L SteenwykDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-8436-595X
Antonis RokasDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-7248-6551
Thaila F Dos Reis *Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Laure N A Ries *Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil rieslaure13@gmail.com ggoldman@usp.br.
Gustavo H Goldman *Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil rieslaure13@gmail.com ggoldman@usp.br.ORCID 0000-0002-2986-350X
Universidade de São Paulo · BRUniversidade de Ribeirão Preto · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de São Carlos · BRVanderbilt University · US

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

G-protein coupled receptors (GPCRs) are extracellular signaling receptors that sense environmental cues. Fungi sense their environment primarily through GPCR-mediated signaling pathways, which, in turn, regulate fungal development, metabolism, virulence, and mycotoxin biosynthesis.

Indexed as

Secondary MetabolismAnimalsAspergillus fumigatusCell WallFungal ProteinsGene Expression Regulation, FungalLarvaMacrophagesMaleMelaninsMiceMice, Inbred C57BLMothsPhagocytosisPhosphorylationReceptors, G-Protein-CoupledFungal ProteinsMelaninsReceptors, G-Protein-CoupledTranscription FactorsAspergillus fumigatuscell wallG-protein coupled receptorsecondary metabolitesvirulence

Identifiers

PMID33051372
PMCPMC7554674
OpenAlexW3091768936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.