Evidence map›Paper›PMID 33051368›Full record

ArticlemBio2020

From People to

Denise McAloose, Melissa Laverack, Leyi Wang, Mary Lea Killian, Leonardo C Caserta, Fangfeng Yuan, Patrick K Mitchell, Krista Queen, Matthew R Mauldin, Brittany D Cronk and 27 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 278 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
278citing papers in PubMed, 2 pooled it
60.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

278 citing papers in PubMed, 2 syntheses or guidelines pooled it, 414 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Antimicrobial Resistance inVeterinary sciences · 2026
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  11. Review
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  14. Article
  15. Article
  16. Review
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  18. Article
  19. Review
  20. Four Novel SARS-CoV-2 Infected Feral American Mink (Animals : an open access journal from MDPI · 2025
    Article

218 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 8 institutions in 1 country.

Denise McAloose *Wildlife Conservation Society, Bronx Zoo, Bronx, New York, USA dmcaloose@wcs.org dgdiel@cornell.edu.ORCID 0000-0002-3945-3862
Melissa Laverack *Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Leyi Wang *Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA.
Mary Lea Killian *National Veterinary Services Laboratories, Animal and Plant Health Inspection Service (APHIS), U.S. Department of Agriculture (USDA), Ames, Iowa, USA.
Leonardo C CasertaDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Fangfeng YuanDepartment of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA.
Patrick K MitchellDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Krista QueenCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Matthew R MauldinCenters for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0002-3807-2339
Brittany D CronkDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Susan L BartlettWildlife Conservation Society, Bronx Zoo, Bronx, New York, USA.
John M SykesWildlife Conservation Society, Bronx Zoo, Bronx, New York, USA.
Stephanie ZecWildlife Conservation Society, Bronx Zoo, Bronx, New York, USA.
Tracy StokolDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Karen IngermanWildlife Conservation Society, Bronx Zoo, Bronx, New York, USA.
Martha A DelaneyZoological Pathology Program, College of Veterinary Medicine, University of Illinois, Brookfield, Illinois, USA.
Richard FredricksonVeterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA.
Marina IvančićChicago Zoological Society, Chicago, Illinois, USA.
Melinda Jenkins-MooreNational Veterinary Services Laboratories, Animal and Plant Health Inspection Service (APHIS), U.S. Department of Agriculture (USDA), Ames, Iowa, USA.
Katie MozingoNational Veterinary Services Laboratories, Animal and Plant Health Inspection Service (APHIS), U.S. Department of Agriculture (USDA), Ames, Iowa, USA.
Kerrie FranzenNational Veterinary Services Laboratories, Animal and Plant Health Inspection Service (APHIS), U.S. Department of Agriculture (USDA), Ames, Iowa, USA.
Nichole Hines BergesonNational Veterinary Services Laboratories, Animal and Plant Health Inspection Service (APHIS), U.S. Department of Agriculture (USDA), Ames, Iowa, USA.
Laura GoodmanDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.ORCID 0000-0002-8327-3092
Haibin WangCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Ying FangDepartment of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA.
Colleen OlmsteadVeterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA.
Colleen McCannWildlife Conservation Society, Bronx Zoo, Bronx, New York, USA.
Patrick ThomasWildlife Conservation Society, Bronx Zoo, Bronx, New York, USA.
Erin GoodrichDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
François ElvingerDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
David C SmithNew York State Department of Agriculture and Markets, Albany, New York, USA.
Suxiang TongCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Sally SlavinskiNew York City Department of Health and Mental Hygiene, Queens, New York, USA.
Paul P Calle *Wildlife Conservation Society, Bronx Zoo, Bronx, New York, USA.
Karen Terio *Zoological Pathology Program, College of Veterinary Medicine, University of Illinois, Brookfield, Illinois, USA.
Mia Kim Torchetti *National Veterinary Services Laboratories, Animal and Plant Health Inspection Service (APHIS), U.S. Department of Agriculture (USDA), Ames, Iowa, USA.
Diego G Diel *Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA dmcaloose@wcs.org dgdiel@cornell.edu.ORCID 0000-0003-3237-8940
Cornell University · USWildlife Conservation Society · USUniversity of Illinois Urbana-Champaign · USAnimal and Plant Health Inspection Service · USCenters for Disease Control and Prevention · USChicago Zoological Society · USNew York City Department of Health and Mental Hygiene · USNew York State Department of Agriculture and Markets · US

Funding

Genomic surveillance for antimicrobial resistance in animalsU18FD006716 · FDA · CORNELL UNIVERSITY · PI Laura Brunengraber Goodman · 2019 to 2026
$707k
University of Illinois Veterinary Diagnostic Laboratory participation in Veterinary Laboratory Investigation and Response NetworkU18FD006673 · FDA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Chien-Che Hung · 2019 to 2026
$387k
Evaluation of the iSeq platform for E. coli pathotypingU18FD006714 · FDA · CORNELL UNIVERSITY · PI GOODMAN, LAURA BRUNENGRABER · 2019 to 2019
$225k
Development of a harmonized method for sequencing Listeria monocytogenes on iSeqU18FD006866 · FDA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MADDOX, CAROL W., WANG, LEYI · 2019 to 2019
$97k
FDA HHS U18 FD006673FDA HHS U18 FD006714FDA HHS U18 FD006716FDA HHS U18 FD006866
6 · The paper itself

Abstract

Despite numerous barriers to transmission, zoonoses are the major cause of emerging infectious diseases in humans. Among these, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and ebolaviruses have killed thousands; the human immunodeficiency virus (HIV) has killed millions. Zoonoses and human-to-animal cross-species transmission are driven by human actions and have important management, conservation, and public health implications. The current SARS-CoV-2 pandemic, which presumably originated from an animal reservoir, has killed more than half a million people around the world and cases continue to rise. In March 2020, New York City was a global epicenter for SARS-CoV-2 infections. During this time, four tigers and three lions at the Bronx Zoo, NY, developed mild, abnormal respiratory signs. We detected SARS-CoV-2 RNA in respiratory secretions and/or feces from all seven animals, live virus in three, and colocalized viral RNA with cellular damage in one. We produced nine whole SARS-CoV-2 genomes from the animals and keepers and identified different SARS-CoV-2 genotypes in the tigers and lions. Epidemiologic and genomic data indicated human-to-tiger transmission. These were the first confirmed cases of natural SARS-CoV-2 animal infections in the United States and the first in nondomestic species in the world. We highlight disease transmission at a nontraditional interface and provide information that contributes to understanding SARS-CoV-2 transmission across species.

Indexed as

AnimalsAnimals, ZooBetacoronavirusCoronavirus InfectionsCOVID-19Genome, ViralHaplotypesHumansNew York CityOne HealthPandemicsPantheraPhylogenyPneumonia, ViralSARS-CoV-2Zoonosesin situ hybridizationlionOne HealthPanthera leoPanthera tigrisrRT-PCRSARS-CoV-2tigervirus isolationwhole-genome sequencingzoozoonotic infection

Identifiers

PMID33051368
PMCPMC7554670
OpenAlexW3093141020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.