ArticleJournal of the American Society of Nephrology : JASN2020
Murine Epsins Play an Integral Role in Podocyte Function.
Ying Wang, Christopher E Pedigo, Kazunori Inoue, Xuefei Tian, Elizabeth Cross, Karen Ebenezer, Wei Li, Zhen Wang, Jee Won Shin, Eike Schwartze and 2 more
Article in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors at 2 institutions in 2 countries.
Ying WangDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Christopher E PedigoDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Kazunori InoueDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Xuefei TianDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Elizabeth CrossDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Karen EbenezerDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Wei LiDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Zhen WangDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Jee Won ShinDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Eike SchwartzeDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Marwin GroenerDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-4292-4426
Shuta IshibeDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut shuta.ishibe@yale.edu.ORCID 0000-0003-3212-641X
Yale University · USBeijing University of Chinese Medicine · CN
Funding
Role of Focal Adhesion Kinase (FAK) in Nephrosis and NephritisR01DK083294 · NIDDK · YALE UNIVERSITY · PI ISHIBE, SHUTA · 2010 to 2025
$5.4M
The Role of Endocytosis and Actin Regulation in PodocytesR01DK093629 · NIDDK · YALE UNIVERSITY · PI Shuta Ishibe · 2012 to 2026
$5.1M
MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLINGR01NS036251 · NINDS · YALE UNIVERSITY · PI DE CAMILLI, PIETRO · 1997 to 2021
$4.7M
Molecular Mechanisms in Synaptic Vesicle RecyclingR37NS036251 · NINDS · YALE UNIVERSITY · PI DE CAMILLI, PIETRO · 2010 to 2016
$2.7M
The Srf/Pfn1 Axis in Podocyte BiologyF32DK118863 · NIDDK · YALE UNIVERSITY · PI PEDIGO, CHRISTOPHER E · 2018 to 2018
backgroundEpsins, a family of evolutionarily conserved membrane proteins, play an essential role in endocytosis and signaling in podocytes.
methodsPodocyte-specific
resultsPodocyte-specific loss of epsins resulted in increased albuminuria and foot process effacement. Primary podocytes isolated from these knockout mice exhibited abnormalities in cell adhesion and spreading, which may be attributed to reduced activation of cell division control protein Cdc42 and SRF, resulting in diminished
conclusionsEpsins play an indispensable role in maintaining properly functioning podocytes through the regulation of Cdc42 and SRF-dependent
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Murine Epsins Play an Integral Role in Podocyte Function. · full record | OpenQuestion