Evidence map›Paper›PMID 33051308›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2021

Koushik Muralidharan, Anudeep Yekula, Julia L Small, Zachary S Rosh, Keiko M Kang, Lan Wang, Spencer Lau, Hui Zhang, Hakho Lee, Chetan Bettegowda and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 81 citations in OpenAlex.

  1. Response Rate and Molecular Correlates to Encorafenib and Binimetinib in BRAF-V600E Mutant High-Grade Glioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
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  19. Recent Developments in Blood Biomarkers in Neuro-oncology.Current neurology and neuroscience reports · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 1 country.

Koushik MuralidharanDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Anudeep YekulaDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Julia L SmallDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-7135-6299
Zachary S RoshDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Keiko M KangDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Lan WangDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Spencer LauDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Hui ZhangBiostatistics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Hakho LeeCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-0087-0909
Chetan BettegowdaDepartment of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Michael R ChicoineDepartment of Neurosurgery, Washington University Medicine in St. Louis, St. Louis, Missouri.
Steven N KalkanisDepartment of Neurosurgery, Henry Ford Health System, Detroit, Michigan.
Ganesh M ShankarDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Brian V NahedDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-8537-106X
William T CurryDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-8036-1847
Pamela S JonesDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Daniel P CahillDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Leonora Balaj *Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Balaj.Leonora@mgh.harvard.edu Bcarter@mgh.harvard.edu.
Bob S Carter *Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Balaj.Leonora@mgh.harvard.edu Bcarter@mgh.harvard.edu.
Massachusetts General Hospital · USCenter for Systems Biology · USHenry Ford Health System · USJohns Hopkins University · USUniversity of California San Diego · USWashington University in St. Louis · US

Funding

The role of microvesicles in giloma virotherapyP01CA069246 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHIOCCA, E. ANTONIO · 1996 to 2021
$30.9M
Liquid Biopsy for treatment stratification of IDH1.R132H and EGFRvIII mutant gliomasU01CA230697 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CARTER, BOB S, SKOG, JOHAN · 2018 to 2022
$4.0M
Imaging and Liquid Biopsy for Glioma Diagnosis and Treatment MonitoringR01CA239078 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BALAJ, LEONORA, LEE, HAKHO · 2020 to 2024
$3.1M
exRNA Biomarkers for Human GliomaUH3TR000931 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARTER, BOB S, HOCHBERG, FRED H · 2015 to 2017
$3.0M
Standardized Molecular Analyses of Glioma EVsR01CA237500 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CARTER, BOB S, LEE, HAKHO · 2020 to 2024
$3.0M
exRNA Biomarkers for Human GliomaUH2TR000931 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARTER, BOB S, HOCHBERG, FRED H · 2013 to 2014
$1.1M
Perioperative Targeted Genotyping in GliomaK08NS107634 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SHANKAR, GANESH · 2019 to 2023
$966k
NCATS NIH HHS UH2 TR000931NCATS NIH HHS UH3 TR000931NCI NIH HHS P01 CA069246NCI NIH HHS R01 CA237500NCI NIH HHS R01 CA239078NCI NIH HHS U01 CA230697NINDS NIH HHS K08 NS107634
6 · The paper itself

Abstract

purposeLiquid biopsy offers a minimally invasive tool to diagnose and monitor the heterogeneous molecular landscape of tumors over time and therapy. Detection of EXPERIMENTAL

designHere, we developed a novel digital droplet PCR (ddPCR) assay that incorporates features to improve sensitivity and allows for the simultaneous detection and longitudinal monitoring of two

resultsIn baseline performance in tumor tissue, the assay had perfect concordance with an independently performed clinical pathology laboratory assessment of

conclusionsOur results demonstrate the feasibility of detecting circulating cfDNA

Indexed as

AdultAgedBiomarkers, TumorBrain NeoplasmsCell Line, TumorCohort StudiesDNA Mutational AnalysisFeasibility StudiesFemaleGliomaHumansLiquid BiopsyMaleMiddle AgedMutationPolymerase Chain ReactionBiomarkers, TumorTelomeraseTERT protein, human

Identifiers

PMID33051308
PMCPMC7785705
OpenAlexW3092108641

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.