Evidence map›Paper›PMID 33051304›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2021

Similarities in Risk for COVID-19 and Cancer Disparities.

Lisa A Newman, Robert A Winn, John M Carethers

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 50 citations in OpenAlex.

  1. A Demographic Look at Cancer Treatment Behaviors during the COVID-19 Pandemic.medRxiv : the preprint server for health sciences · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Long-term Outcomes of Patients With HIV andOpen forum infectious diseases · 2023
    Article
  13. Breast cancer care amidst a pandemic: a scoping review to understand the impact of coronavirus disease 2019 on health services and health outcomes.International journal for quality in health care : journal of the International Society for Quality in Health Care · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Lisa A NewmanDepartment of Surgery, Weill Cornell Medicine, New York, New York.
Robert A WinnMassey Cancer Center and Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.ORCID https://orcid.org/0000-0001-5948-9291
John M CarethersDepartments of Internal Medicine and Human Genetics and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan. jcarethe@umich.edu.ORCID https://orcid.org/0000-0003-2623-7332
Cancer Genetics (United States) · USCornell University · USVirginia Commonwealth University · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
Research Education CoreU54CA202997 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI NAYLOR, KEITH BRIAN, TUSSING-HUMPHREYS, LISA · 2015 to 2024
$13.8M
Research Education CoreU54CA203000 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GIACHELLO, AIDA L · 2015 to 2024
$12.4M
The Chicago Cancer Health Equity Collaborative (ChicagoCHEC)U54CA202995 · NCI · NORTHEASTERN ILLINOIS UNIVERSITY · PI CIECIERSKI, CHRISTINA, FEINGLASS, JOSEPH M · 2015 to 2024
$9.5M
The influence of structural violence and individual behavior and health on the gut microbiome and colorectal cancer riskU54MD012523 · NIMHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WINN, ROBERT A. · 2017 to 2022
$7.9M
Reducing racial disparities in lung cancer outcomes by decoding neighborhood contextual environment (RECODE)R01MD014839 · NIMHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KIM, SAGE J., WINN, ROBERT A. · 2021 to 2025
$3.2M
Cancer Health Equity Career Development ProgramT32CA057699 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Marian L. Fitzgibbon · 2018 to 2026
$3.0M
(PQ3) Immune Modulation of DNA Mismatch Repair in Colorectal CancerR01CA206010 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARETHERS, JOHN M · 2016 to 2020
$1.8M
NCI NIH HHS P30 CA016059NCI NIH HHS R01 CA206010NCI NIH HHS T32 CA057699NCI NIH HHS U54 CA202995NCI NIH HHS U54 CA202997NCI NIH HHS U54 CA203000NIMHD NIH HHS R01 MD014839NIMHD NIH HHS U54 MD012523
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is a novel infectious disease that has spread worldwide. In the United States, COVID-19 disproportionately affects racial and ethnic minorities, particularly African Americans, with an observed 2-fold higher rate for hospitalization and greater than 2-fold higher rate for death as compared with White Americans. The disparity seen with COVID-19 is consistent with patterns of disparities observed for cancer; it is well documented that 5-year survival rates for multiple cancers are lower in African Americans compared with White Americans. Root cause contributions for the disparity overlap between COVID-19 and cancer. While cancer is a genetic disease that is influenced by tissue microenvironment, COVID-19 is an infectious disease that is enabled by cellular expression of angiotensin-converting enzyme 2 receptors. However, socioeconomic disadvantages, level of education, lifestyle factors, health comorbidities, and limited access to medical care appear to fuel underlying risk for both cancer and COVID-19 disparities. In addition to African Americans demonstrating higher risk of acquiring and dying from either disease, they are underrepresented in clinical trials involving cancer or COVID-19. Long-term disparities are present with survivorship from cancer and may be likely with survivorship from COVID-19; both have revealed untoward effects on postdiagnosis economic viability for African Americans. Collaborative strategies that include community engagement, diverse participation in cancer and COVID-19 clinical trials, providing insurance for affected persons who lost employment due to either disease, and supporting safety-net and public hospitals for health care access will be critical to stem these disparities.

Indexed as

Health Status DisparitiesAngiotensin-Converting Enzyme 2Black or African AmericanCOVID-19FemaleGenetic Predisposition to DiseaseHealth Services AccessibilityHospitalizationHumansMaleNeoplasmsRisk FactorsSARS-CoV-2Tumor MicroenvironmentWhite PeopleACE2 protein, humanAngiotensin-Converting Enzyme 2

Identifiers

PMID33051304
PMCPMC7785577
OpenAlexW3092135559

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.